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- E-ISSN 2288-8985
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Study on the confirmation of drinking at the bloods & urines used 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2007, v.20 no.3, pp.204-212
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(2007). Study on the confirmation of drinking at the bloods & urines used 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol. Analytical Science and Technology, 20(3), 204-212.
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Abstract
The study was carried out to investigate the ratio of ethanol to n-propanol in blood and urine specimens, and developed a method for distinguishing ingested ethanol from artifactual ethanol in urine samples. In case of no urinary ethanol was detected, the ratio of ethanol to n-propanol concentration was about 12~20 times higher than those of blood. Therefore, it might be a good method to determine whether the detected ethanol is from drinking or from microbial fermentation. During the metabolism of ethanol, the levels of the metabolite of serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) were decreased, while 5-hydroxytryptophol (5-HTOL) was increased. The levels of 5-HTOL/5-HIAA in urine samples of drinking suspects were greater than 1, in that of no drinking suspects were less than 1.
- keywords
- n-propanol, serotonin, 5-HIAA, 5-HTOL
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