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- E-ISSN 2288-8985
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Qunatitative analysis of liquiritin and glycyrrhizin in glycyrrhizae radix by HPLC-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2007, v.20 no.4, pp.331-338
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(2007). Qunatitative analysis of liquiritin and glycyrrhizin in glycyrrhizae radix by HPLC-MS/MS. Analytical Science and Technology, 20(4), 331-338.
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Abstract
Licorice, Glycyrrhizae Radix is widely used as a herbal medicines and a dietary supplements in EastAsia. We employed high performance liquid chromatography electrospray ionization tandem mass spectrometryRadix were ionized by positive ion pneumatically assisted electrospray and detected by HPLC-MS/MS in themultiple-reaction monitoring (MRM) mode using precursor . product ion combinations at m/z 436.2 . 257.0and 823.4 . 453.4, respectively. The assay had a calibration range from 10 to 3,000 ng/mL. The limits ofdetection (LOD) of the liquiritin and glycyrrhizin were 0.4 ng/mL and 0.01 ng/mL, respectively. Theto 113 % and 0.95 to 1.8 %, respectively. According to the above results, HPLC-MS/MS method permitsassignment of tentative structures such as liquiritin and glycyrrhizin in the Glycyrrhizae Radix.
- keywords
- Glycyrrhizae Radix, HPLC-MS/MS, liquiritin, glycyrrhizin
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