- P-ISSN 1225-0163
- E-ISSN 2288-8985
- Log In/Sign Up
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
Development of a method for the determination of 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone in dust using liquld chromatography tandem mass spectrometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2015, v.28 no.1, pp.1-7
https://doi.org/10.5806/AST.2015.28.1.1
&
(2015). Development of a method for the determination of 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone in dust using liquld chromatography tandem mass spectrometry. Analytical Science and Technology, 28(1), 1-7, https://doi.org/10.5806/AST.2015.28.1.1
- Downloaded
- Viewed
Abstract
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco specific nitrosamine found only intobacco products. The ability to monitor biomarker concentrations is very important in understanding environmentaltobacco smoke (ETS). In this study, an efficient and sensitive method for the analysis of NNK in dust wasdeveloped and validated using liquid chromatography tandem mass spectrometry. Dust was collected with filterpaper soaked in methanol. The standard solution and dust sample were diluted with 100 mM ammonium acetateand extracted using dichloromethane. Our calibration curves ranged from 25 to 104 pg/mL. Excellent linearitywas obtained with correlation coefficient values between 0.9996 and 1.0000. The limit of detection (LOD) was5 pg/mL (S/N ≥ 3) and the retention time was 10 min. The limit of quantification (LOQ) was 25 pg/mL, andthe acceptance criteria was the rate of 98-103% (80-120% at levels up to 3×LOQ). The coefficient of variations(CV) was 2.8%. Accuracies determined from dust samples spiked with four different levels of NNK racurvesranged that from 25 to 104 pg/mL. Excellent linearity was obtained between 92.1% and 114%. The precisionof the method was acceptable (5% of CV). The recovery rates of the whole analytical procedure at low, medium,and high levels were 105.7-116.5% for NNK. The carry-over effects during LC-MS/MS analysis were notobserved for NNK. This manuscript summarizes the scientific evidence on the use of markers to measure ETS.
- keywords
- 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Environmental tobacco smoke (ETS) Tobacco-specific nitrosamines (TSNAs) LC-MS/MS Dust
Reference
1
1. Lyon, In ‘International Agency for Research on Cancer’, Monogr Eval Carcinog Risks Hum, 83, p1-1438, France 2004.
2
2. W. O. Spitzer, V. Lawrence, R. Dales, G. Hill, M. C. Archer, P. Clark, L. Abenhaim, J. Hardy, J. Sampalis and S. P. Pinfold, Clin Invest Med., 13(1), 17-42 (1990).
3
3. R. A. Jenkins, M. R. Guerin and B. A. Tomkins, ‘The Chemistry of Environmental Tobacco Smoke: Composition and Measurement’. Lewis Publisher, Boca Raton, Florida, 2000.
4
4. D. Hoffmann, I. Hoffmann and K. El Bayoumy, Chem. Res. Toxico., 14, 767-790 (2001).
5
5. G. E. Matt, P. J. Quintana, H. Destaillats, L. A. Gundel, M. Sleiman, B. C. Singer, P. Jacob III, N. Benowitz, J. P. Winickoff, V. Rehan, P. Talbot, S. Schick, J. Samet, Y. Wang, B. Hang, M. MartinsGreen, J. F. Pankow and M. F. Hovell, Environ Health Perspect, 119, 1218-26 (2011).
6
6. Lyon, In ‘International Agency for Research on Cancer’, Monogr Eval Carcinog Risks Hum, 37, p1-291, France, 1985.
7
7. J. M. Yuan, W. P. Koh, S. E. Murphy, Y. H. Fan, R. W. Wang, S. G. Carmella, S. M. Han, K. Wickham, Y. T. Gao, M. C. Yu and S. S. Hecht, Cancer Res., 69, 2990-2995 (2009).
8
8. S. S. Hecht, Chem. Res. Toxicol., 11, 559-603 (1998).
9
9. A. Burton, Environ Health Perspect, 119, A70-4 (2011).
10
10. J. P. Winickoff, J. Friebely, S. E. Tanski, C. Sherroda, G. E. Matt, M. F. Hovell and R. C. McMillen, Pediatrics, 123, e74-9 (2009).
11
11. M. W. Seong, J. S. Moon, J. H. Hwang, H. J. Ryu, S. J. Kang, S. Y. Kong, T. H. Um, J. G. Park, J. S. Lee and D. H. Lee, Clinica Chimica Acta, 411(1-2), 72-76 (2010).
12
12. L. Gatzke-Kopp and T. Beauchaine, Child Psychiatry Hum Dev, 38, 255-69 (2007).
13
13. C.-J. Hsieh, S.-F., Jeng, Y.-N. Su, H.-F. Liao, W.-S. Hsieh, K.-Y. Wu and P.-C. Chen, Nicotine Tob Res., 12, 1108-1117 (2010).
14
14. J. Makin, P. A. Fried and B. Watkinson, Neurotoxicol Teratol., 13, 5-12 (1991).
15
15. D. P. Strachan and D. G. Cook, Thorax, 52, 905-14 (1997).
16
16. D. G. Cook and D. P. Strachan, Thorax, 52, 1081-94 (1997).
17
17. D. G. Cook, D. P. Strachan and I. M. Carey, Thorax, 53, 884-93 (1998).
18
18. S. H. Hwang, J. H. Hwang, J. S. Moon and D. H. Lee, Korean J Pediatr, 55(2), 35-41 (2012)
19
19. G. E. Matt, P. J. E. Quintana, M. F. Hovell, J. T. Bernert, S. Song, N. Novianti, T. Juarez, J. Floro, C. Gehrman, M. Garcia and S. Larson, Tob Control, 13, 29-37 (2004).
20
20. N. Ramirez, M. Z. Ozel, A. C. Lewis, R. M. Marce, F. Borrull, J. F. Hamilton, J. Chromatogr A., 1219, 180-187 (2012).
21
21. Food and Drug Administration, http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatory Information/Guidances/UCM070107, Accessed 17.04.09.
22
22. H. Hongwei, Z. Xiaotao, T. Youngfeng, T. Gangling, L. Yulan, H. Qingyuan, Tian Youngfeng, Tang Gangling, Liu Yulan and Hu Qingyuan, J. Pharm. Biomed. Anal, 63, 17-22 (2012).
Other articles from this issue
- Development of a method for the determination of 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone in dust using liquld chromatography tandem mass spectrometry
- Electrochemical gas sensor based on Pt-Ru-Mo/MWNT electrocatalysts and vinyl ionic liquids as electrolyte
- Development and validation of a selective and sensitive LC-MS/MS method for determination of misoprostol acid in human plasma: Application to bioequivalence study
- Evaluation of the consistency and homogeneity of artificial latent fingerprint printed with artificial sweat
- Characterization of CdS-quantum dot particles using sedimentation field-flow fractionation (SdFFF)
- Optimization of hydrochar generated from real food waste using titration methods
- Acidification and neutralization characteristics of size-fractionated atmospheric aerosols at Gosan site of Jeju Isalnd
- Concentration distributions and formation characteristics of trihalomethanes in drinking water supplies to rural communities
- Development of intracellular organelle markers using modified glycolipid-binding peptides in mammalian cells
- Effect of Angelica gigas extract powder on progress of osteoarthritis induced by monosodium iodoacetate in rats
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.