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Vol.10 No.3
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A comprehensive review on Tukhm-e-Karafs (Apium graveolens L.) with special reference to Unani System of Medicine

CELLMED / CELLMED, (P)3022-6805; (E)3022-6791
2020, v.10 no.3, pp.20-20
https://doi.org/10.5667/CellMed.2020.0020
Mohd Naushad (Sanskriti Unani Medical College & Hospital)
Mohammad Zakir (National Research Institute of Unani Medicine for Skin Disorders (NRIUMSD))
Najmus Sahar (Department of Ilmul Advia, National Research Institute of Unani Medicine for Skin Disorders)
Munawwar Husain Kazmi (National Research Institute of Unani Medicine for Skin Disorders)
Mohd, N. , Mohammad, Z. , Najmus, S. , & Munawwar, H. K. (2020). A comprehensive review on Tukhm-e-Karafs (Apium graveolens L.) with special reference to Unani System of Medicine. CELLMED, 10(3), 20-20, https://doi.org/10.5667/CellMed.2020.0020
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Abstract

The Karafs is a dried herb of whole plant of Apium graveolens L. from Apiaceae (carrot family). The seeds (fruits) of Apium graveolens are known as Tukhm-e- Karafs in Unani Medicine. Karafs is known as Celeri in French, Apio in Spanish, Selderiji in Dutch, Syelderey in Russian and Chin in Chinese. It is cultivated in different parts of the world for its seeds as spice and green leaves and root as salad crop. Its seeds are also used for medicinal purposes in complementary and alternative medicines. In Unani it is used as a single drug or as an ingredient in compound formulations used for management in various ailments. The seeds have various pharmacological actions like hepatoprotective, diuretic and lithotriptic etc. It is commonly found in Western Asia, Europe, North Africa and various parts of India like Punjab, Uttar Pradesh and Himachal Pradesh etc. In Unani its actions are described as Mudirr-i-Bawl (Diuretic), Mufattit-i-Hasāh (Lithotriptic), Dafi‘-i-Tashannuj (Antispasmodic) and Kāsir-i-Riyāh (Carminative). It is used for the treatment of Hasah al-Kulya (Nephrolithiasis), Nafkh al-Mi‘da (Flatulence), Istisqā’ (Oedema) and Ihtibās al-Bawl (Retention of urine) etc.

keywords
Apigenin, Apium graveolens, Karafs, Kulya, Nephrolithiasis, Unani

Reference

1.

Ahmed N, NasreenF, Husain S, Alam S, Ahmed S, Rahman K. Evaluation of the analgesic activity of Tukhme Karafs (Apium graveolensLinn.) in swiss albino mice. J Sci Inn Res. 2015; 4(4): 172-174.

2.

Ahmed QS, Sayedda K. Effect of Celery (Apium graveolens) Seeds Extract onProtease Inhibitor (Ritonavir) Induced Dyslipidemia, NJIRM. 2012; 3(1):52-56.

3.

Al-Howiriny T,Alsheikh A,Alqasoumi S,Al-Yahya M,ElTahir K,Rafatullah S. Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats, Pharmaceutical Biology. 2010;48(7):786-93.

4.

Al-Snafi AE. The Pharmacology of Apium graveolens. -A Review.International Journal for Pharmaceutical Research Scholars (IJ). 2014;3(1);671-677.

5.

Anonymous. ENVIS centre on medicinal plants, Encyclopedia on Indian Medicinal Plants, http://envis.frlht.org/bot_search. (Accessed on January, 2019)

6.

Anonymous. National Formulary of Unani Medicine, Vol. I 1st Reprint Edn. Department of AYUSH, Ministry of Health & Family Welfare, Govt. of India, pp. 46, 2006.

7.

Azam KM. Muheet-e-Azam, (New Delhi, India; Central Council for Research in Unani Medicine), pp. 254, 2012.

8.

Baananou S, Bouftira I, Mahmoud A, Boukef K, Marongiu B, Boughattas NA., Antiulcerogenic and antibacterial activities ofApium graveolensessential oil and extract, Nat Prod Res.2013;27(12):1075-83.

9.

Boonruamkaew P, Sukketsiri W, Panichayupakaranant P, Kaewnam W, Tanasawet S, Tipmanee V, Hutamekalin P, Chonpathompikunlert P., Apium graveolensextract influences mood and cognition in healthy mice, J Nat Med.2017;71(3):492-505

10.

Chonpathompikunlert P, Boonruamkaew P, Sukketsiri W, Hutamekalin P, and Sroyraya M. The antioxidant and neurochemical activity of Apium graveolensL. and its ameliorative effect on MPTP-induced Parkinson-like symptoms in mice, BMC Complementaryand Alternative Medicine. 2018;18:103.

11.

Choochote W, Tuetun B, Kanjanapothi D, Rattanachanpichai E, Chaithong U, Chaiwong P, Jitpakdi A,Tippawangkosol P,Riyong D,Pitasawat B. Potential of crude seed extract of celery,Apium graveolensL., against the mosquito Aedes aegypti(L.) (Diptera: Culicidae), J Vector Ecol.2004;29(2):340-6.

12.

Desu BSR and Sivaramakrishna K. Anti-depressant activity of methanolic extract of Apium graveolensseeds. Int J Res. in Pharm Chem. 2012;2(4):1124-1127.

13.

Dolati K, Rakhshandeh H, Golestani M, Forouzanfar F, Sadeghnia R and Sadeghnia H.R., Inhibitory Effects ofApium graveolenson Xanthine Oxidase Activity and Serum Uric Acid Levels in Hyperuricemic Mice, Prev Nutr Food Sci. 2018;23(2): 127-133.

14.

Dymock W, Warden CJH, Hooper D. Pharmacographia Indica, Vol. II. (Delhi, India; M/s Bishan Singh MahendraPal Singh, Dehradun & M/s Periodical Experts, Vivek Vihar), pp.122-124, 1891.

15.

Fazal SS, ingla RK. Review on the Pharmacognostical & Pharmacological Characterization of Apium graveolensLinn. Indo Global Journal of Pharmaceutical Sciences. 2012; 2(1), 36-42.

16.

Ghani HMN. Khazainul Advia. (New Delhi, India; Idara Kitabul Shifa), pp. 206-208, 2011.

17.

Zhou H,Ye M,Xu W,Yu M,Liu XandChen Y. DL-3-n-butylphthalide therapy for Parkinson's disease: A randomized controlled trial, Experimental and Therapeutic Medicine. 2019;17(5): 3800–3806.

18.

Hakim MA. Bustanul Mufradat, (New Delhi, India; Idara Kitabus Shifa), pp. 58, 2002.

19.

Ibn Sina. al-Shaykh al-Ra’is Abu ‘Ali al-Husayn ibn ‘Abd Allah [980-1037 AD], 1998, Al-Qanun fi’l Tibb, Urdu Translation by Hk. Gulam HusainKantoori, Idara Kitabul Shifa, New Delhi, pp. 125-126.

20.

Ibne-Baytar. Aljame-al-Mufridat-Al-advia wal Aghzia (Urdu translation)[1197-1248 AD] vol.4th, (New Delhi, India; CCRUM), pp.139-144, 2003.

21.

Iyer D,Patil UK. Assessment of Antihyperlipidemic and Antitumor Effect of Isolated Active Phytoconstituents from Apium graveolensL. through Bioassay-Guided Procedures. J Diet Suppl.2019;16(2):193-206.

22.

Jorge VG, Angel JRL, Adrián TS, Francisco AC, Anuar SG, Samuel ES, Angel SO, Emmanuel HZ. Vasorelaxant activity of extracts obtained from Apium graveolens: Possible source for vasorelaxantmolecules isolation with potential antihypertensive effect. Asian Pac. J. Trop. Biomed. 2013; 3(10):776-779.

23.

Kabiruddin H. Makhzanul Mufradat, (Deoband, India; Faisal Publication), pp.450, 2000.

24.

Kirtikar KR, Basu BD. Indain Medicinal Plants, vol-5, 2nd edition, (Dehradun, India; Oriental Enterprises), pp.1668-1670, 1995.

25.

Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy, 54thedtion, (Maharashtra, India; Nirali prakashan), pp.14.31-14.32, 2017.

26.

Kooti W, Mansouri E, Ghasemiboroon M, Harizi M, Larky DA, Afrisham R. The Effects of Hydro-alcoholic Extract of Apium graveolensLeaf on the Number of Sexual Cells and Testicular Structure in Rat, Jundishapur J. Nat. Pharm. Prod. 2014; 9(4):e17532.

27.

Momin R. Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds of Apium graveolensLinn seeds, Phytomedicine. 2002; 9:312-318.

28.

Muhammad Nasir Ali. Nasirul Moalijeen, (Lucknow, India; Alwi Muhammad Ali Bakhsh Publisher), pp. 104, 1860.

29.

Nabi MG. Makhzan-ul-Mufridat Wa Murakkabat Azam Al-maroof Khawasul-Advia,(New Delhi, India; CCRUM), pp.35, 2007.

30.

Nadkarni KM. Indian Materia Medica, vol.1, (Bombay, India;Popular Prakashan), pp.119-120, 2000.

31.

Pulliaiah T. Encyclopaedia of World Medicinal Plants, vol-1, (New Delhi, India; Regency Publication),pp. 187-188, 2006.

32.

Qarshi. ‘Ala’ al-Din ‘Ali ibn Abi al-Hazm [1210-1288 AD], Moalajat-i Sadidi (urdu translation by Syed Abid Husain), Matba‘ Nami, Munshi Nawal Kishor, Kanpur, pp. 57.

33.

Quality Standards of Indian Medicinal Plants, vol. 13, (New Delhi, India; Medicinal Plant Division Indian Council of Medical Research), pp.48-59, 2015.

34.

Sarshar S,Sendker J,Qin X,Goycoolea FM,Asadi Karam MR,Habibi M,Bouzari S,Dobrindt U,Hensel A. Antiadhesive hydroalcoholic extract from Apium graveolensfruits prevents bladder and kidney infection against uropathogenic E. coli.,Fitoterapia. 2018;127: 237-244.

35.

Singh A, Handa SS. HepatoprotectiveactivityofApium graveolensand Hygrophila auriculataagainst paracetamol and thioacetamide intoxication in rats, J Ethnopharmacol.1995;15;49(3):119-26.

36.

Sultana S,Ahmed S,Jahangir T,Sharma S. Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development, Cancer Lett.2005;18;221(1):11-20.

37.

Suzana B,Marija G, Milica K, Milica V, Bojana M, Milica M, Mirjana R. Spasmolytic Activity of the Aqueous and Ethanol Celery Leaves (Apium graveolensL.) Extracts on the Contraction of Isolated Rat Ileum, Acta Medica Medianae. 2015; 54(2):11-16.

38.

The Unani Pharmacopoeia of India, Department of Ayush, Ministry of Health & family Welfare, Govt. of India, Part-I, vol. II, pp.93-94, 2007.

39.

The Wealth of India ‘Raw Materials’, Vol.2, New Delhi, C.S.I.R., pp.93, 1950.

40.

Varadharajan S., Kalathil K., Asokkumar K., Muthuswamy U.A.S. and Jagannath P., Induction of Apoptosis and Cytotoxic Activities of Apium graveolensLinn. Using invitro Models. Midd-East J Sci Res.2011; 9 (1): 90-94.

41.

Wesam Kooti et al. The Effects of Hydro-Alcoholic Extract of Celery on Lipid Profile of Rats Fed a High Fat Diet, Advances in Environmental Biology.2014;8(9);325-330

42.

Xiang J,Pan J,Chen F,Zheng L,Chen Y,Zhang S,Feng W. L-3-n-butylphthalide improves cognitive impairment of APP/PS1 mice by BDNF/TrkB/PI3K/AKT pathway, Int J Clin Exp Med. 2014;15;7(7):1706-13.

43.

Yang XD,Cen ZD,Cheng HP,Shi K,Bai J,Xie F,Wu HW,Li BB,Luo W. L-3-n-Butylphthalide Protects HSPB8 K141N Mutation-Induced Oxidative Stress by Modulating the Mitochondrial Apoptotic and Nrf2 Pathways, Front. Neurosci. 2017;12;11:402.

44.

Ye X,Rong Z,Li Y,Wang X,Cheng B,Cheng Y,Luo H,Ti Y,Huang X,Liu Z,Zhang YW,Zheng W,Zheng H. Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy. Front. Pharmacol. 2018; 11;9:734.

45.

Ying Gong, Weiguo Liu, Xin Huang, Lina Hao, Yiman Li, andShujuan Sun, Antifungal Activity and Potential Mechanism of N-Butylphthalide Alone and in Combination With Fluconazole Against Candida albicans, Front.Microbiol.2019;10:1461.

46.

Zhang C, Zhao S, Zang Y, Gu F, Mao S, Feng S, Hu L, and Zhang C. The efficacy and safety ofDl-3n-butylphthalide on progressive cerebral infarction arandomized controlled STROBE study, Medicine (Baltimore). 2017; 96(30): e7257.

47.

Zhang Y,Huang LJ, Shi S,Xu SF, Wang XL, Peng Y. L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer’s Disease, CNS Neuroscience & Therapeutics. 2016;22(12):979-987.

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