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Cognitive Improvement Effect of Resplex Alpha A in the Scopolamine-induced Mouse Model

CELLMED / CELLMED, (P)3022-6805; (E)3022-6791
2023, v.13 no.14, pp.1-1
https://doi.org/10.5667/CellMed.2023.014
Bong-Keun Jang (JBK-LAB, Inc.)
Youngsun Kwon (JBK-LAB, Inc.)
Sunyoung Park (JBK-LAB, Inc.)
Gunwoo Lee (JBK-LAB, Inc.)
Hye-yeon Kang (JBK-LAB, Inc.)
Jeom-Yong Kim (JBK-LAB, Inc.)
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Abstract

Administration of Scopolamine can be considered a psychopharmacological model of Alzheimer's disease (AD). We made an animal model of Alzheimer's disease (AD) by administering Scopolamine to Blab/c mice. In this study, we investigated the effects of Resplex Alpha on memory impairment and cognitive function in mice in a mouse animal model of Scopolamine-induced memory impairment. Through Y-mazed and passive avoidance behavioral assays, we observed that Resplex Alpha recovered Scopolamine-induced short-term memory and cognitive functions. The results of our study imply that Resplex Alpha may be beneficial in the prevention of Alzheimer's disease (AD).

keywords
Resveratrol-alginate nano-complex (RANCP), Ginkgo biloba extract (EGb231), Cognitive function, Memory dysfunction, Alzheimer’s disease (AD), dementia

CELLMED