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- P-ISSN3022-6805
- E-ISSN3022-6791
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ISSN : 3022-6805
Study on the Anti-hypertension mechanism of Prunella Vulgaris based on entity grammar systems
Man-man Li (Beijing University of Chinese Medicine)
Bai-Xia Zhang (Beijing University of Chinese Medicine)
Shuai-Bing He (Beijing University of Chinese Medicine)
Ya-Nam Hu (Beijing University of Chinese Medicine)
Yun Wang (Beijing University of Chinese Medicine)
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Abstract
Literatures and experimental studies have shown that Prunella has an effect on anti-hypertension, however, its components are complicated, so that it is still difficult to clear the specific roles of its various components in blood pressure regulation in. So we decide to systematically study the anti-hypertension mechanism of Prunella. We integrated multiple databases and constructed molecular interaction network between the chemical constituents of Prunella Vulgaris and hypertension based on entity grammar systems model. The network has 262 nodes and 802 edges. Then we infer the interactions between chemical compositions and disease targets to clarify the anti-hypertension mechanism. Finally, we found Prunella could influence hypertension by regulating apoptosis, cell proliferation, blood vessel development and vasoconstriction, etc. Thus this study provides reference for drug development and compatibility, and also gives guidance for health care at a certain extent.
- keywords
- Prunella Vulgaris, hypertension, mechanism, entity grammar systems
Reference
Baraba´si AL, Oltvai ZN. Network biology: understanding the cell’s functional organization. Nature Reviews Genetics. 2004;5:101-113.
Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China. (Beijing, China: Chemical Industry Press), 2010.
Díez J, Panizo A, Hernández M, Pardo J. Is the Regulation of Apoptosis Altered in Smooth Muscle Cells of Adult Spontaneously Hypertensive Rats? Hypertension. 1997; 29:776-780.
Ding J, Romani J, Zaborski M, MacLeod RA, Nagel S, Drexler HG, Quentmeier H. Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2. PLOS One. 2013;8:e83510.
Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH. Potentiation of Bradykinin by Angiotensin-(1-7) on Arterioles of Spontaneously Hypertensive Rats Studied In Vivo. Hypertension. 2001;37:703-709.
Gilmour K M, Perry S F. Carbonic anhydrase and acid-base regulation in fish. J Exp Biol. 2009;212:1647-1661.
Goh K-I, Cusick ME, Valle D, Childs B, Vidal M, Barabasi AL. The human disease network. Proceedings of the National Academy of Sciences. 2007;104:8685-8690.
He XY, Zhao SM, Gong RC. The Mechanism Study of Lowering the Blood Pressure of Rabbit with Prunella Asiatica Nakai. J Tonghua Teachers College. 2002;23:100-102.
Ito A, Lai CH, Zhao X, Saito S, Hamilton MH, Appella E, Yao TP. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J. 2001;20:1331-1340.
Jiang WY, LV ZP, Pang GF, HU CY, Wei DZ, Yang JL. Assessment of cerebrovascular reactivity with transcranial D oppler CO2 test in the elderly hypertensives. Chin J Cerebiovase Dis. 2007;4:401-404.
Kitano H. Systems biology: a brief overview. Science. 2002;295:1662-1664.
Kobet E, Zeng X, Zhu Y, Keller D, Lu H. MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins. Proc Natl Acad Sci USA. 2000;97: 12547-12552.
Kosan C, Ginter T, Heinzel T, Krämer OH. STAT5 acetylation Mechanisms and consequences for immunological control and leukemogenesis. JAKSTST. 2013;2:e26102.
Li X, Wu L, Liu W, Jin Y, Chen Q, Wang L, Fan X, Li Z, Cheng Y. A Network Pharmacology Study of Chinese Medicine QiShenYiQi to Reveal Its Underlying Multi-Compound, Multi-Target, Multi-Pathway Mode of Action. PLoS One. 2014;9:1-11.
Li YY, Zhang H, Xu J, Qian Y, Lu XZ, Yang B, Chen M, Yang ZJ, Cao KJ. Bradykinin β2 receptor -58T/C gene polymorphism and essential hypertension: a meta-analysis. PLOS one. 2012;7:e43068.
Liu Y, Xing ZB, Zhang JH, Fang Y. Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18. FEBS Lett. 2013;587:847-853.
Lu Y, Hwang SL, Son JK, Chang HW. Manassantin B isolated from Saururus chinensis inhibits cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Fyn-mediated nuclear factor-kappa B and mitogen activated protein kinase pathways in bone marrow derived-mast cells. Biol Pharm Bull. 2013;36:1370-1374.
Lynch DK, Daly RJ. PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBO J. 2002;21:72-82.
Ma SK, Choi JS, Joo SY, Kim HY, Kim CS, Bae EH, Lee JU, Kim SW. Activation of the Renal PI3K/Akt/mTOR Signaling Pathway in a DOCA-Salt Model of Hypertension. Chonnam Med J. 2012;48:150-154.
Nakayama T, Soma M, Watanabe Y, Hasimu B, Sato M, Aoi N, Kosuge K, Kanmatsuse K, Kokubun S, Marrow JD, Oates JA. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. Biochem Biophys Res Commun. 2002;297:1135-1139.
Natekar A, Olds RL, Lau MW, Min K, Imoto K, Slavin TP. Elevated blood pressure: Our family’s fault? The genetics of essential hypertension. World J Cardiol. 2014;6:327-337.
Palacios EH, Weiss A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene. 2004;23:7990-8000.
Pan XL, Ren RJ, Wang G, Tang HD, Chen SD. The Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer’s disease. Neurosci Bull. 2010;26:241-246.
Ruan C, Ma Y, Li Y, Ge Q, Zhu D, Gao P. 6B.04: COMPLEMENT-INHIBITED PERIVASCULAR ADIPONECTIN EXPRESSION CONTRIBUTES TO VASCULAR INJURY IN HYPERTENSIVE MICE. J Hypertens. 2015;33:e76-77.
Seo KW, Lee SJ, Ye BH, Kim YW, Bae SS, Kim CD. Mechanical stretch enhances the expression and activity of osteopontin and MMP-2 via the Akt1/AP-1 pathways in VSMC. J Mol Cell Cardiol. 2015;85:13-24.
Shi SH, Cai YP, Cai XJ, Zheng XY, Cao DS, Ye FQ, Xiang Z. A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease. PLoS One. 2014;9:1-19.
Siddique H, Rao VN, Reddy ES. CBP-mediated post-translational N-glycosylation of BRCA2. Int J Oncol. 2009;35:387-391.
Simister PC, Feller SM.. Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies. Mol BioSyst. 2012;8:33-46.
de Totero D, Meazza R, Capaia M, Fabbi M, Azzarone B, Balleari E, Gobbi M, Cutrona G, Ferrarini M, Ferrini S. The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways. Blood. 2008;111:517-524.
Wang B, Dang A, Liu G. Genetic variation in the promoter region of the beta2 bradykinin receptor gene is associated with essential hypertension in a Chinese Han population. Hypertens Res. 2001;24:299-302.
Wang Y. Entity grammar systems: a grammatical tool for studying the hierarchal structures of biological systems. Bull Math Biol. 2004;66:447-471.
Wang Z, Li G, Tse W, Bunting KD. Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood. 2009;113:4856-4865.
Xu SR, Jin G, Li W, Jin F. Vasodilative Effect of Prunella vulgaris Linn on Thoracic Aorta of Rats in vitro. Sichuan J Traditional Chinese Medicine. 2010;28:52-54.
You SM, Zhu YT. Effect of Common Selfheal Fruit-Spike on blood pressure in spontaneously hypertensive rates. Strait Pharmaceutical J. 2011;23:37-38.
Zamoyska R, Basson A, Filby A, Legname G, Lovatt M, Seddon B. The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol Rev. 2003;191:107-118.
Zhang BX, Song KK, Li YW, Zhang YL, Li ZY, Wang Y. Study on mechanism of Tianzhu Powder in treatment of vascular dementia based on system pharmacology. China Journal of Traditional Chinese Medicine and Pharmacy. 2015;30:1425-1431.
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