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Tuberculosis & Respiratory Diseases

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Vol.58 No.1
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Propylthiouracil 약제 복용으로 유발된 미만성 폐출혈 1예

A Case of Propylthiouracil Induced DiffusePulmonary Hemorrhage

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2005, v.58 no.1, pp.78-82
이승룡 (고려대학교)
이승현 (고려대학교)
이상엽 (고려대학교)
김제형 (고려대학교)
신철 (고려대학교)
심재정 (고려대학교)
인광호 (고려대학교)
강경호 (고려대학교)
유세화 (고려대학교)
정진용 (고려대학교)
이경주 (고려대학교)
김세중 (고려대학교)
이은주 (고려대학교)
허규영 (고려대학교)
정혜철 (고려대학교)
이승룡, 이승현, 이상엽, 김제형, 신철, 심재정, 인광호, 강경호, 유세화, 정진용, 이경주, 김세중, 이은주, 허규영, & 정혜철. (2005). Propylthiouracil 약제 복용으로 유발된 미만성 폐출혈 1예. Tuberculosis & Respiratory Diseases, 58(1), 78-82.
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Abstract

Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar he morrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderin- laden macrophages. Such findings suggested propylthiouracil induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea. (Tuberc Respir Dis 2005; 58:78-82)

keywords
Propylthiouracil, ANCA, Diffuse alveolar hemorrhage, Propylthiouracil, ANCA, Diffuse alveolar hemorrhage

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