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Tuberculosis & Respiratory Diseases

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Vol.59 No.5
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Oxaliplatin, 5-fluorouracil, leucovorin 병합항암화학요법 중에 발생한 폐섬유화증 1예

Pulmonary Fibrosis Under Chemotherapy with Oxaliplatin, 5-fluorouracil, and Leucovorin

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2005, v.59 no.5, pp.536-540
정진용 (고려대학교)
이승룡 (고려대학교)
신철 (고려대학교)
심재정 (고려대학교)
최인근 (고려대학교)
서재홍 (고려대학교)
유세화 (고려대학교)
인광호 (고려대학교)
강경호 (고려대학교)
이상엽 (고려대학교)
김제형 (고려대학교)
허규영 (고려대학교)
정기환 (고려대학교)
정혜철 (고려대학교)
정진용, 이승룡, 신철, 심재정, 최인근, 서재홍, 유세화, 인광호, 강경호, 이상엽, 김제형, 허규영, 정기환, & 정혜철. (2005). Oxaliplatin, 5-fluorouracil, leucovorin 병합항암화학요법 중에 발생한 폐섬유화증 1예. Tuberculosis & Respiratory Diseases, 59(5), 536-540.
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초록

저자들은 64세 남자 환자에서, 재발성 위암에 대한 oxaliplatin, 5-fluorouracil, leucovorin 병합화학요법 중에 발생한 폐섬유화증의 임상적 진단 및 스테로이등 충격 요법 치료 후 호전된 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

keywords
Oxaliplatin, Fluorouracil, Leucovorin, Chemotherapy, Pulmonary fibrosis, Oxaliplatin, Fluorouracil, Leucovorin, Chemotherapy, Pulmonary fibrosis

Abstract

The combination of oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) has recently been shown to be beneficial in advanced colorectal and gastric cancers. The side effects of this regimen include neutropenia, diarrhea and neurosensory toxicity. However, case reports on the pulmonary toxicities of this regimen are very limited. Especially, the development of pulmonary fibrosis has never been cited in the literature. Herein is reported the case of a patient treated with oxaliplatin, 5-fluorouracil and leucovorin combination chemotherapy in whom pulmonary fibrosis developed, but which improved after steroid pulse therapy. (Tuberc Respir Dis 2005; 59: 536-540)

keywords
Oxaliplatin, Fluorouracil, Leucovorin, Chemotherapy, Pulmonary fibrosis, Oxaliplatin, Fluorouracil, Leucovorin, Chemotherapy, Pulmonary fibrosis

참고문헌

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Tuberculosis & Respiratory Diseases

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