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Right Ventricle Ejection Fraction Contributes Severity of Dyspnea in Chronic Obstructive Pulmonary Disease(COPD)

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2006, v.60 no.6, pp.631-637







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Abstract

Background: Patients with COPD generally complain of very different degrees of dyspnea regardless of their pulmonary function. The study, we assessed the right ventricular ejection fraction in relation to dyspnea in COPD patient.Methods: The pulmonary function including the diffusion capacity was measured. The right ventricle ejection fraction (RVEF) was measured using a first-pass radionuclide scan by multigated acquisition (MUGA). Forty patients with chronic obstructive pulmonary disease (COPD) were stratified for dyspnea according to the Medical Research Council (MRC) scale. Moderate dyspnea and severe dyspnea is defined as MRC 2/3 (n = 16) and MRC 4/5 (n = 24) respectively. Results: The baseline pulmonary function tests including DLCO and the resting arterial blood gas were similar in the moderate and severe dyspnea group, with the exception of the residual volume (% predicted) (moderate 160 ± 27, severe 210 ± 87, p < 0.03). The right ventricle ejection fraction was significantly (p < 0.001) lower in the severe dyspnea group (25 ± 8) than in the moderate group (35 ± 6). The independent factor assessed by multiple logistic regression revealed only the severity of dyspnea to be significantly associated with RVEF (p < 0.02).Conclusion: This study showed that the right ventricle ejection fraction would contributes to severity of dyspnea in patients with a similar pulmonary function (Tuberc Respir Dis 2006; 60: 631-637)

keywords
COPD, Ejection fraction, Dyspnea.

Reference

1.

(2004) The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease,

2.

(2002) Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD,

3.

(1992) A factor analysis of dyspnea ratings,respiratory muscle strength,and lung function in patients with chronic obstructive pulmonary disease,

4.

(1994) Factor analysis of exercise of exercise capacity,dyspnoea ratings and lung function in patients with severe COPD,

5.

(1984) Chest wall mechanics during exercise in patients with severe chronic air-flow obstruction,

6.

(1995) Muscle strength,symptom intensity,and exercise capacity in patients with cardiorespiratory disorders,

7.

(1996) Respiratory muscle and cardiopulmonary function during exercise in very severe COPD,

8.

(1999) Ventilatory drive at rest and perception of exertional dyspnea in severe COPD,

9.

(1996) Inhaledbronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease,

10.

(1993) Exertional breathlessness in patients with chronic airflow limitation:the role of lung hyperinflation,

11.

(1972) Patterns of cardiovascular dysfunction in chronic obstructive lung disease,

12.

(1982) Physiologic correlates of right ventricular ejection fraction in chronic obstructive pulmonary disease:a combined radionuclide and hemodynamic study,

13.

(1991) Right ventricular volumes determined by computerized thermodilution in ischaemic heart disease:effect of exercise and nitroglycerin,

14.

(1987) Bedside evaluation of right ventricular performance using a rapid computerized thermodilution method,

15.

(2004) Change of lung volumes in chronic obstructive pulmonary disease patients with improvement of airflow limitation after treatment,

16.

(eurrespirj1993) official statement of the European Respiratory Society,

17.

(2005) Importance of carbon monoxide transfer coefficient(KCO)interpretation in patients with airflow limitation,

18.

(1987) Measurement of right and left ventricular volumes in healthy individuals with cine MR imaging,

19.

(1984) Right and left ventricular ejection fraction and left ventricular volume changes at rest and during exercise in normal subjects,

20.

(2004) Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume,cardiac performance,or the response to volume infusion in normal subjects,

21.

(1978) Assessment of cardiac performance with quantitative radionuclide angiocardiography:right ventricular ejection fraction with reference to findings in chronic obstructive pulmonary disease,

22.

(1977) Right ventricular ejection fraction in severe chronic airway obstruction,

23.

(2002) Effect of lung volume reduction surgery for severe emphysema on right ventricular function,

24.

(2005) Severe pulmonary hypertension and chronic obstructive pulmonary disease,

25.

(2001) Natural history of pulmonary hypertension in a series of 131 patients with chronic obstructive lung disease,

26.

(2003) Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease,

27.

(1995) Right ventricular function in patients with severe COPD evaluated for lung transplantation.Lung Transplant Group,

28.

(1984) Right ventricular performance and central circulatory hemodynamics during upright exercise in patients with chronic obstructive pulmonary disease,

29.

(1980) Right and left ventricular exercise performance in chronic obstructive pulmonary disease:radionuclide assessment,

30.

(1980) First pass radionuclide assessment of right and left ventricular ejection fraction in chronic pulmonary disease:effect of oxygen upon exercise response,

31.

(1987) Effect of dynamic airway compression on breathing pattern and respiratory sensation in severe chronic obstructive pulmonary disease,

32.

(1995) Pathophysiology of dyspnea,

33.

(1968) The influence of the airways resistance and alveolar pressure on the pulmonary vascular resistance in chronic bronhcitis,

34.

(1991) Impairment of endothelium-dependent pulmonary- artery relaxation in chronic obstructive lung disease,

35.

(1998) Endothelial dysfunction in pulmonary arteries of patients with mild COPD,

36.

(1995) Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension,

37.

(2001) Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers,

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