Development of Prediction Equation of Diffusing Capacity of Lung for Koreans
박용범 (한림대학교)
윤형규 (가톨릭대학교)
임성용 (성균관대학교)
김태형 (한양대학교)
박주헌 (아주대학교)
리원연 (연세대학교)
박승주 (전북대학교)
이세원 (울산대학교)
김우진 (강원대학교)
김기욱 (부산대학교)
신경철 (영남대학교)
김두진 (순천향대학교)
김휘정 (원광대학교)
김태은 (건국대학교병원)
유광하 (건국대학교)
심재정 (고려대학교)
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Abstract
Background: The diffusing capacity of the lung is influenced by multiple factors such as age, sex, height, weight, ethnicity and smoking status. Although a prediction equation for the diffusing capacity of Korea was proposed in the mid-1980s, this equation is not used currently. The aim of this study was to develop a new prediction equation for the diffusing capacity for Koreans. Methods: Using the data of the Korean National Health and Nutrition Examination Survey, a total of 140 nonsmokers with normal chest X-rays were enrolled in this study. Results: Using linear regression analysis, a new predicting equation for diffusing capacity was developed. For men, the following new equations were developed: carbon monoxide diffusing capacity (DLco)=–10.4433–0.1434×age (year)+0.2482×heights (cm); DLco/alveolar volume (VA)=6.01507–0.02374×age (year)–0.00233×heights (cm). For women the prediction equations were described as followed: DLco=–12.8895–0.0532×age (year)+0.2145×heights (cm) and DLco/VA=7.69516–0.02219×age (year)–0.01377×heights (cm). All equations were internally validated by k-fold cross validation method. Conclusion: In this study, we developed new prediction equations for the diffusing capacity of the lungs of Koreans. A further study is needed to validate the new predicting equation for diffusing capacity.
- keywords
- Korean, Pulmonary Diffusing Capacity, Diffusion, Carbon Monoxide
참고문헌
Gold WM. Pulmonary function testing. In: Mason RJ, Broaddus VC, Murray JF, Nadel JA, editors. Murray and Nadel's textbook of respiratory medicine. 4th ed. Philadelphia: Elsevier Saunders; 2005. p. 695-703.
Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 2005;26:720-35.
Crapo RO, Gardner RM. DLCO reference equations: a perspective. Am Rev Respir Dis 1986;134:856.
Yang SC, Yang SP, Lin PJ. Prediction equations for singlebreath carbon monoxide diffusing capacity from a Chinese population. Am Rev Respir Dis 1993;147:599-606.
Korotzer B, Ong S, Hansen JE. Ethnic differences in pulmonary function in healthy nonsmoking Asian-Americans and European-Americans. Am J Respir Crit Care Med 2000;161(4 Pt 1):1101-8.
Pesola GR, Huggins G, Sherpa TY. Abnormal predicted diffusion capacities in healthy Asians: an inequality with a solution. Respiration 2006;73:799-807.
Chhabra SK, Kumar R, Gupta UA. Prediction equations for diffusing capacity (transfer factor) of lung for North Indians. Lung India 2016;33:479-86.
Park JO, Choi IS, Park KO. Normal predicted values of singlebreath diffusing capacity of the lung in healthy nonsmoking adults. Korean J Intern Med 1986;1:178-84.
Song EH, Oh YM, Hong SB, Shim TS, Lim CM, Lee SD, et al. Selection of reference equations for lung volumes and diffusing capacity in Korea. Tuberc Respir Dis 2006;61:218-26.
Ra SW, Park TS, Hong Y, Hong SB, Shim TS, Lim CM, et al. Clinical usefulness and the accuracy of Korean reference equation for diffusing capacity. Tuberc Respir Dis 2008;64:80-6.
Burrows B, Kasik JE, Niden AH, Barclay WR. Clinical usefulness of the single-breath pulmonucy diffusing capacity test. Am Rev Respir Dis 1961;84:789-806.
Crapo RO, Morris AH. Standardized single breath normal values for carbon monoxide diffusing capacity. Am Rev Respir Dis 1981;123:185-9.
Paoletti P, Viegi G, Pistelli G, Di Pede F, Fazzi P, Polato R, et al. Reference equations for the single-breath diffusing capacity: a cross-sectional analysis and effect of body size and age. Am Rev Respir Dis 1985;132:806-13.
Roca J, Rodriguez-Roisin R, Cobo E, Burgos F, Perez J, Clausen JL. Single-breath carbon monoxide diffusing capacity prediction equations from a Mediterranean population. Am Rev Respir Dis 1990;141(4 Pt 1):1026-32.
Standardization of lung function tests. Report working party. Bull Eur Physiopathol Respir 1983;19 Suppl 5:1-95.
Korean Center for Disease Control and Prevention. Korean National Health & Nutrition Examination Survey. Cheongju: Korean Center for Disease Control and Prevention; 2017 [cited 2017 Oct 10]. Available from: https://knhanes.cdc.go.kr/knhanes/main.do.
Hwang YI, Park YB, Yoo KH. Recent trends in the prevalence of chronic obstructive pulmonary disease in Korea. Tuberc Respir Dis 2017;80:226-9.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005;26:319-38.
Choi JK, Paek D, Lee JO. Normal predictive values of spirometry in Korean population. Tuberc Respir Dis 2005;58:230-42.
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