Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases
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Abstract
Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functionsin the living system. Recently, our understanding of the molecular mechanisms underlying aging biology has significantlyadvanced. Interestingly, many of the pivotal molecular features of aging biology are also found to contribute to thepathogenesis of chronic lung disorders such as chronic obstructive pulmonary disease and idiopathic pulmonaryfibrosis, for which advanced age is the most crucial risk factor. Thus, an enhanced understanding of how molecularfeatures of aging biology are intertwined with the pathobiology of these aging-related lung disorders has paramountsignificance and may provide an opportunity for the development of novel therapeutics for these major unmet medicalneeds. To serve the purpose of integrating molecular understanding of aging biology with pulmonary medicine, in thisreview, recent findings obtained from the studies of aging-associated lung disorders are summarized and interpretedthrough the perspective of molecular biology of aging.
- keywords
- Lung Aging, Aging Biology, Pulmonary Disease, Chronic Obstructive, Idiopathic Pulmonary Fibrosis
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