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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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전이 췌장암 환자의 Gemcitabine과 방암탕 가감방 및 건칠단 병용투여 치험 1례

A Case Report of Patient with Metastatic Pancreatic Cancer Treated with modified Bangam-tang and Gunchil-dan in conjunction with Gemcitabine

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.2, pp.1-9
https://doi.org/10.15432/JKTO.2018.23.2.001
김은혜 (강동경희대학교 한방암센터 한방내과)
윤성수 (강동경희대학교 한방암센터 한방내과)
이지영 (강동경희대학교 한방병원 한방내과)
윤성우 (경희대학교)
김은혜, 윤성수, 이지영, & 윤성우. (2002). 전이 췌장암 환자의 Gemcitabine과 방암탕 가감방 및 건칠단 병용투여 치험 1례. 대한한의학회지, 23(2), 1-9, https://doi.org/10.15432/JKTO.2018.23.2.001
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Abstract

Objectives: This study was aimed to report a patient with metastatic pancreatic cancer treated with modified Bangam-tang and Gunchil-dan in conjunction with gemcitabine. There were better survival-related outcomes compared to gemcitabine alone. Methods: The patient with metastatic pancreatic cancer received gemcitabine as palliative chemotherapy since June 2016 concurrent with modified Bangam-tang and Gunchil-dan since October 2016 to October 2017. To evaluate the effect of treatment, tumor markers (carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA)), Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, and overall survival were checked. Adverse events were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Results: After 12 months with the combination treatment, levels of CA19-9 were decreased from 8747 to 265.7 ng/ml and CEA from 42.2 to 6.5 U/ml. Clinical partial response state was shown until May 2, 2017 and stable disease state was maintained from August 4, 2017. In March 2018, the patient got an operation including pancreatectomy and diagnosed with no evidence of disease state in September, 2018. In conclusion, it showed the overall survival of 29 months from June, 2016 to November, 2018. Serious adverse events were not identified. Conclusions: This study suggested that combined treatment with modified Bangam-tang and Gunchil-dan may show better outcome in patient with metastatic pancreatic cancer than gemcitabine alone.

keywords
Bangam-tang, Gunchil-dan, Gemcitabine, Pancreatic cancer, Korean medicine, Herbal medicine


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