A Case of End-stage non-small cell Lung Cancer Patient with Brain Metastasis Treated with Pembrolizumab with Integrative Medicine Therapy

서한길; 진용재; 송미화; 김인태; 박지혜; 정준석; 조성규; 박재후; 신광순

doi:10.15432/JKTO.2018.23.2.011

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P-ISSN1010-0695
E-ISSN2288-3339

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P-ISSN 1010-0695
E-ISSN 2288-3339

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23권 2호

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Pembrolizumab과 통합의학치료로 호전된 뇌전이 동반 말기 비소세포성 폐암 환자 1례

A Case of End-stage non-small cell Lung Cancer Patient with Brain Metastasis Treated with Pembrolizumab with Integrative Medicine Therapy

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339

2002, v.23 no.2, pp.11-25

https://doi.org/10.15432/JKTO.2018.23.2.011

서한길 (장덕한방병원)
진용재 (장덕한방병원)
송미화 (장덕한방병원)
김인태 (장덕한방병원)
박지혜 (장덕한방병원)
정준석 (장덕한방병원)
조성규 (장덕한방병원)
박재후 (장덕한방병원)
신광순 (장덕한방병원)

서한길, 진용재, 송미화, 김인태, 박지혜, 정준석, 조성규, 박재후, & 신광순. (2002). Pembrolizumab과 통합의학치료로 호전된 뇌전이 동반 말기 비소세포성 폐암 환자 1례. 대한한의학회지, 23(2), 11-25, https://doi.org/10.15432/JKTO.2018.23.2.011

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Abstract

Objective: The purpose of this study is to report the case of a patient with non-small cell lung cancer (NSCLC) with Programmed cell death protein 1 (PD-1) mutation treated by Integrative Medicine Therapy (IMT). Methods: A patient with metastatic NSCLC received pembrolizumab 200mg intravenously for every 3 weeks from July 2017. Repeat cycle every 3 weeks since July 2017. The patient has been treated with Integrative Medicine Therapy (IMT) since December 2016. The tumor size was measured by computed tomography (CT) and magnetic resonance imaging(MRI). Adverse events were evaluated by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0. Results: After combined treatment, the extent of proximal portion of primary tumor in the left lower lobe was decreased and disease status was stable radiologically. No evidence of newly developed metastatic lesions in the brain since May 2017. The patient did not experience any adverse event according to NCI-CTCAE ver. 5.0. Conclusion: This case study suggests that Integrative Medicine Therapy (IMT) may contribute to tumor response, in conjunction with Pembrolizumab on the treatment of patients with NSCLC.

keywords: Non-Small-Cell Lung cancer, Integrative Medicine, Metastasis, Korean Herbal Medicine, Pembrolizumab.

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Pembrolizumab과 통합의학치료로 호전된 뇌전이 동반 말기 비소세포성 폐암 환자 1례

A Case of End-stage non-small cell Lung Cancer Patient with Brain Metastasis Treated with Pembrolizumab with Integrative Medicine Therapy

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