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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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흰쥐 足底에 formalin주입으로 유발된 痛症反應에 대한 電鍼效果

Effects of Electroacupuncture on the Modulation of Formalin-induced Pain in the Rat

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.2, pp.285-295
김재효 (원광대학교)
최동옥 (원광대학교)
김민선 (원광대학교)
박병림 (원광대학교)
손인철 (원광대학교)
김재효, 최동옥, 김민선, 박병림, & 손인철. (2002). 흰쥐 足底에 formalin주입으로 유발된 痛症反應에 대한 電鍼效果. 대한한의학회지, 23(2), 285-295.
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Abstract

Objective : Acupuncture is useful method to treat many of pain in the oriental cultural medicine. Especially when hetero-segmental area' acu-points were stimulated, the therapeutic effects of pain control have more critical property than other methods of acupuncture. However, the mechanism of pain control by acupuncture is contradicted so far. The present study was examined that the effects of electro-acupuncture (EA) applied to the acu-point of hetero-segmental area on modulation of formalin induced pain in Sprague-Dawley rats.Methods : In order to apply EA to acu-points in the plantar area of right fore paws, a pair of teflen-coated stainless steel wires were implanted in HT 7 (Shin-Moon) and PC 7 (Dae-Reung) 7 days before behavioral test. A behavioral test was performed by means of video camera after injection of 5% formalin (50 ul) into the lateral plantar region of left hind paw. EA was delivered by a constant DC current stimulator at 4~5 mA, 2 ms, and 10 Hz for 30 min. c-Fos protein expression was measured in the lumbar spinal cord at 2 hr and 4 hr after formalin injection.Results : Behavioral responses including favoring, flinching and bitting were occured in the biphasic pattern, such as the 1st phase (0~5 min) and the 2nd phase (20~45 min) after formalin injection. However, EA (4~5 mA, 2 ms, 10 Hz) significantly inhibited the behavioral responses. Injection of formalin expressed c-Fos protein on the ipsilateral dorsal horn neurons in L3 - L5 and the expression was sustained more than 4 hrs after formalin injecion. However, EA decreased c-Fos protein expression at dorsal horn neurons in the lumbar spinal cord till 4hrs after formalin injection.Conclusions : These results suggest that EA modulates formalin induced pain and the inhibitory action may be elicited by the descending inhibitory system.

keywords
electro-acupuncture, formalin induced pain, c-Fos, pain modulation., electro-acupuncture, formalin induced pain, c-Fos, pain modulation.


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