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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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環跳(GB30) 電鍼刺戟이 一過性 前腦虛血로 유발된 c-Fos 단백질 발현에 미치는 影響

Effect of Electroacupuncture of GB30 on the Expression of c-Fos following Transient Forebrain Ischemia in Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.2, pp.296-306
김재효 (원광대학교)
김풍식 (원광대학교)
김경식 (원광대학교)
김민선 (원광대학교)
박병림 (원광대학교)
손인철 (원광대학교)
김재효, 김풍식, 김경식, 김민선, 박병림, & 손인철. (2002). 環跳(GB30) 電鍼刺戟이 一過性 前腦虛血로 유발된 c-Fos 단백질 발현에 미치는 影響. 대한한의학회지, 23(2), 296-306.
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Abstract

(Objective) Acupuncture and herbal medicine have been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. However, it was not published the protective effect of the electroacupuncture (EA) of Huan-do (GB30) on the transient forebrain ischemia injury.(Methods) The neuroprotective effects of EA (2 ms, 10 Hz, and 1 - 2 mA) of GB30 on the transient forebrain ischemia injury were investigated by immunohistochemistry of c-Fos like protein in Sprague-Dawley rats. (Results) The transient forebrain ischemia injury resulted in increased expression of c-Fos like protein (cFL) in the dentate gyrus (DG) and CA1 for 6 hrs after ischemia, and EA increased significantly expression of cFL in the CA1 and DG. For 48 hrs after, there was delayed expression of cFL at the CA1 and DG, representing the sign of neuronal cell death, but EA decreased the delayed expression of cFL, significantly. (Conclusion) These results suggest that the neuroprotective effects of EA on transient forebrain ischemia injury may be related to excitatory regulation of cFL at the early stage and inhibitory regulation at the long term.

keywords
transient forebrain ischemia, electroacupuncture, GB30, immediate early gene, c-Fos, hippocampus., transient forebrain ischemia, electroacupuncture, GB30, immediate early gene, c-Fos, hippocampus.


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