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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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麝香蘇合元이 정상인의 심박변이도에 미치는 영향

The Effect of Sahyangsohapwon on Heart Rate Variability of Healthy Subjects

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2009, v.30 no.1, pp.120-127
김창현 (경희대학교)
황재웅 (경희대학교)
민인규 (경희대학교)
변형식 (경희대학교)
박성욱 (경희대학교)
박정미 (경희대학교)
고창남 (경희대학교)
배형섭 (경희대학교)
정우상 (경희대학교)
문상관 (경희대학교)
조기호 (경희대학교)
김영석 (경희대학교)
김미영 (경희대학교)
나병조 (경희대학교)
김창현, 황재웅, 민인규, 변형식, 박성욱, 박정미, 고창남, 배형섭, 정우상, 문상관, 조기호, 김영석, 김미영, & 나병조. (2009). 麝香蘇合元이 정상인의 심박변이도에 미치는 영향. 대한한의학회지, 30(1), 120-127.
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Abstract

Objectives: Sahyangsohapwon (SS) is a herbal medication that has been widely used with circulatory and neural diseases. This study was conducted to assess the effect of SS on the autonomic nervous system by using heart rate variability measurement. Methods: The eligible subjects were enrolled from the healthy male group of ages 20 to 35 years. They were divided into two groups, the SS group (n=26) and the control (n=24). We monitored the ECG of subjects from the time period 14:00 to 18:00. In the SS group, subjects were administered with a dose of SS at the time 15:00, whereas the control group had none. For each hour HRV measurement was monitored every 15 minutes for 512 seconds from the time period 14:00 to 18:00. The mean value, which was calculated using the 4 values during each hour (i.e. 14:00, 14:15, 14:30, 14:45), was used as the representative value for each individual hour. For the measurement values, RR-interval and SDNN (standard deviation of the NN intervals) were used as time domain analysis, and HF (high frequency), LF (low frequency), and LF/HF ratio were used as frequency domain analysis. Results: The LF value showed an increase after one hour of SS administration and showed gradual diminution for each and every hour. The repeated measures of ANOVA for the comparison of the LF value between the SS group and the control group showed significant differences. While, RR interval, SDNN, HF, and LF/HF ratio values showed no significant differences between the two groups. Conclusions: We suggest that the SS might be useful for stabilizing autonomic nervous system by inhibiting sympathetic nerve activation in healthy people.

keywords
Heart rate variability, HRV, Sahyangsohapwon, autonomic nervous system


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