- P-ISSN 1010-0695
- E-ISSN 2288-3339
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effects of Polyporus Herbal-acupuncture at KI10 on LPS-induced nephritis in rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2015, v.36 no.3, pp.73-83
&
(2015). Effects of Polyporus Herbal-acupuncture at KI10 on LPS-induced nephritis in rats. , 36(3), 73-83.
- 0Downloaded
- 210Viewed
Abstract
Objectives: The purpose of this study was to evaluate the effects of Polyporus Herbal-acupuncture(PO-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats. Methods: Rats were allocated into normal, control, and 2 experimental groups. The rats in the control group were intra-peritoneally injected with LPS for nephritis induction. The rats in the groups of experiment 1 and experiment 2 were treated with Saline injection, and PO-HA, respectively at KI10 three times for a week and then intra-peritoneally injected with LPS. To evaluate the effects of PO-HA at KI10, WBC count in blood, creatine, tumor necrosis factor-alpha (TNF-α), cytokine-induced neutrophil chemoattractant 1(CINC-1) in serum, urinary volume, creatinine, total protein in urine, myeloperoxidase(MPO) in kidney were measured. Results: PO-HA at KI10 significantly suppressed the increase of WBC in blood, TNF-α, CINC-1 in serum, MPO in kidney of LPS-stimulated rats. PO-HA at KI10 significantly suppressed the increase creatinine, total protein in urine of LPS-stimulated rats. Conclusions: According to these results, it is postulated that PO-HA at KI10 has an anti-inflammatory and renal-protective effects on LPS-induced nephritis in rats. Therefore, it is suggested that PO-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
- keywords
- LPS-induced nephritis, Polyporus Herbal-acupuncture, KI10
Reference
1
1. Du HK. Oriental Kidney System Internal Medicine. Seoul:Institute of the oriental science. 1993:226, 228, 247, 238-47, 326, 334-6, 361-2, 454-9, 514-6.
2
2. Du HK. Oriental Kidney System Internal Medicine. Seoul:Institute of the oriental science. 1993:225, 238-47, 256-7, 334-5, 359-401.
3
3. Committee of Korean Textbook Publisher. Herbology. 6th ed. Seoul:Yeong Lim Sa. 1999:304-5.
4
4. Kim CM, Shin MK, Ahn DK, Lee KS. The encyclopedia of Oriental herbal medicine. Seoul:Jung Dam. 2004:3700.
5
5. Sun Y, Yasukawa K. New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus. Bioorganic &Medicinal Chemistry Letters. 2008;18:3417-20.
6
6. Ohsawa T, Yukawa M, Takao C, Murayama M, Bando H. Studies on constituents of fruit body of Polyporus umbellatus and their cytotoxic activity. Chem Pharm Bull. 1992;40:143-7.
7
7. Oh YH, Lee UY, Lee MW, Shim MJ, Lee TS. Immnuo-modulatory and Antitumor Effect of Crude Polysaccharides Extracted from Sclerotium of Grifolia umbellata. The Korean Journal of Mycology. 2004;32:23-30.
8
8. Zhang Y, Liu Y, Yan SC. Effect of Polyporus umbellatus polysaccahride on function of macrophages in the peritoneal cavities of mice with lesions. Cheih Ho Tsa Chih. 1991;11:211-5.
9
9. May L, Yun SC. Therapeutic investigation of Polyporus umbellatus polysaccahride on the children with pure immunity. J Traditional Chinese Medicine. 1990;3:168-9.
10
10. Chang YF, Liu YY, Yun SC. Effect of Polyporus umbellatus polysaccahrides on macrophages of liver damaged mice. Intergrated J Chinese and Western Medicine. 1991;11:225-6.
11
11. Xiong LL. Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B. Cheih Ho Tsa Chih. 1993;13:516-7.
12
12. Korean Pharmacopuncture institute. Aqua -acupuncture and clinical use. Seoul:Korean Pharmacopuncture institute. 1997:1-5.
13
13. Textbook Compilation Committee of Korean acupuncture & moxibustion medicine society. The acupuncture and Maxivustion (volumeⅠ). Seoul:JipMoonDang. 2001:531-63, 1457-60.
14
14. Choi MS, Ko HK, Kim CH. A study on aqua-acupuncture. Journal of Korean acupuncture & moxibustion medicine society. 1990;7(1):315-29.
15
15. Meridian & Acupoint Compilation Committee of Korean Oriental Medical Colleges. Detail of meridians & acupoints (volumeⅡ) : a guidebook for college students. Daejeon:JongRyeoNaMu. 2012:634-6.
16
16. Kim KM, Lee H, Kang HJ, Lee YH, Yim YK. Anti-inflammatory Effect of Dianthi Semen Herbal-acupuncture at KI10 on nephritis in rats. Journal of Meridian & Acupoint. 2009;26(1):66-77.
17
17. Park BM, Hur B, Yim YK. Anti-inflammatory Effect of Plantaginis Semen Herbal-acupuncture at KI10 on LPS-induced nephritis in rats. Journal of Meridian & Acupoint. 2009;26(2):127-43.
18
18. Lee JH, Kim JH, Kim YI. Anti-inflammatory Effect of Benincasae Semen Herbal-acupuncture at KI10 on nephritis in rats. Journal of pharmacopuncture. 2010;13(2):51-65.
19
19. Yoon KS, Kang JH, Lee H. Anti-inflammatory Effect on Desmodii Herba Pharmacopuncture at KI10 on Nephritis in Rats. Journal Of Korean Acupuncture & Moxibustion Medicine Society. 2011;28(3):43-54.
20
20. Cho E, Kang JH, Lee H. Anti-inflammatory Effect of Akebiae Lignum Parmacopuncture at KI10 on LPS-induced Acute Nephritis in Rats. The Journal Of Korean Acupuncture &Moxibustion Medicine Society. 2012;29(3):41-53.
21
21. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signal activation of adaptive immunity. Nature. 1997;388(6640):394-7.
22
22. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. 2000 ; 406(6797) : 782-7.
23
23. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, et al. Toll-like receptor 4(TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J immunol. 1999;162(7):3749-52.
24
24. Baumgartner J-D, Cohen J. Septic shock Pathogenesis. Lancet. 1991;338:732-6.
25
25. Ohmori Y, Hamilton TA. A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem Biophys Res Commun. 1990;168:1261-7.
26
26. Tannenbaum CS, Koemer TJ, Jansen MM, Hamilton TA. Characteriation of Lipopolysaccharide -induced macrophage gene expression. J immunol. 1988;140:3640-5.
27
27. Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 4th ed. trans. Kang JS et al. Seoul: PanMunSa. 2002:23-40, 240-3, 567-8.
28
28. Harada A, Sekido N, Akahoshi T, Wada T, Mukaida N, Matsushima K. Essential involvement of interleukin-8(IL-8) in acute inflammation. Journal of Leukocyte Biology. 1994;56:559-64.
29
29. Matsushima K, Morishita K, Yoshimura T, Lavu S, Kobayashi Y, Lew W, et al. Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J. Exp. Med. 1988;167:1883–93.
30
30. Strieter RM, Kunkel SL, Showell HJ, Remick DG, Phan SH, Ward PA, et al. Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science. 1989;243:1467-9.
31
31. Sekido N, Mukaida N, Harada A, Nakanishi I, Watanabe Y, Matsushima K. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature. 1993;365:654-7.
32
32. Krawisz JE, Sharon P, Stenson WF. Quantitive assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology. 1984;87:1344-55.
33
33. Song KY, Ji JK, Ham UK. Core Pathology. Seoul:Korea Medical Book Publishing company. 1998:79-80, 573, 576-80.
- 0Downloaded
- 210Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Awareness and attitudes of professors regarding research ethics education in the colleges and the school of Korean Medicine
- Survey on Relationship among Health Relating Factors Sasang Constitution and Stress
- Reliability and Validity Analysis of a Standard Instrument of Diagnosis and Assessment for Spleen Qi Deficiency Pattern in Chronic Dyspepsia Patients
- The Effects of Smoking on Bioelectrical Capacitance Measured at Twelve Source Points: A Cross-Over Study
- Preliminary Study to Develop the Instrument of Oriental Medical Evaluation for Lung Cancer
- The Study of the Relation Between the Body Mass Index and the Dam-Bangkwang Body of Hyung-Sang Medicine in Patients over 45 Years of Age
- Effects of Polyporus Herbal-acupuncture at KI10 on LPS-induced nephritis in rats
- Survey Research for Developing Educational Programs on Clinical Trials of Korean Medicine Devices
- Medical costs for patients with Facial paralysis : Based on Health Big Data
- Study about Analysis of Current Case for Oriental Medical Disputes - With a Focus on the Oriental Medical Injury Relief Data from Korea Consumer Agency -
- Treatments of Psoriasis Occurred After Acute Tonsillitis: Four Case Reports
- The Case Study of Lactobacillus mixture culture fluid on Atopic dermatitis
- A Clinical Report on Facial Atrophic Scars treatment with Acupotomy
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.