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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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한약에 대한 N-of-1 임상시험의 현황 – 문헌 고찰

Current Status of N-of-1 Trials for Herbal Medicine -Literature Review

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2020, v.41 no.1, pp.107-116
https://doi.org/10.13048/jkm.20008
정창운 (청연중앙연구소 주식회사)
전선우 (청연의학연구소)
조희근 (청연의학연구소)
정창운, 전선우, & 조희근. (2020). 한약에 대한 N-of-1 임상시험의 현황 – 문헌 고찰. 대한한의학회지, 41(1), 107-116, https://doi.org/10.13048/jkm.20008
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Abstract

Objectives: To overcome the limitations of randomized controlled trials, many other trials design is tested. The n-of-1 trial is a promising research method in the field of Korean medicine because of this methodology can examine the optimal treatment for each patient strictly. Therefore, we reviewed the status of N-of-1 studies on herbal medicine. Methods: A systematic literature review was conducted based on the pubmed database. The search term were ‘N-of-1 Trial’, ‘Chinese Medicine’, ‘Herbal Medicine’, ‘Kampo’. There was no restriction in year. Results: Four clinical trials have been identified to demonstrate the effectiveness of herbal medicines for Kidney-yin-deficiency syndrome, bronchiectasis and gastric cancer. These studies suggest that the N-of-1 design is a study that encourages patient involvement, demonstrates the effectiveness of herbal medicines and helps reduce unnecessary medication. Conclusion: The N-of-1 clinical trial may be a rigorous methodology suitable for the clinical setting and may help the development of evidence-based Korean medicine. Attention is also needed in this research method in Korea.

keywords
N-of-1, Single Case Studies, Clinical Trial, Herbal Medicine, Korean medicine


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