East Asian Herbal Medicine (EAHM) Alone for the Treatment of Women with Diminished Ovarian Reserve (DOR): A Systematic Review and Meta-analysis

이주현; 최수지; 노은지; 민상연; 김동일

권한신청
P-ISSN1010-0695
E-ISSN2288-3339

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P-ISSN 1010-0695
E-ISSN 2288-3339

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43권 1호

East Asian Herbal Medicine (EAHM) Alone for the Treatment of Women with Diminished Ovarian Reserve (DOR): A Systematic Review and Meta-analysis

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339

2022, v.43 no.1, pp.136-150

이주현 (동국대학교 한의과대학 소아과교실)
최수지 (동국대학교)
노은지 (동국대학교 한의과대학 부인과교실)
민상연 (동국대학교)
김동일 (동국대학교)

이주현, 최수지, 노은지, 민상연, & 김동일. (2022). 난소예비력 저하 여성에 대한 한약 단독 치료의 임신 관련 지표 개선 효과에 관한 체계적 문헌 고찰 및 메타분석. 대한한의학회지, 43(1), 136-150.

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Abstract

Objectives: The aim of this study was to find out whether east asian herbal medicine (EAHM) treatment alone is effective in improving pregnancy-related indicators compared to conventional medicine in women with Diminished Ovarian Reserve (DOR). Methods: We searched eligible studies from PubMed, Cochrane Library, EMBASE, Chinese National Knowledge Infrastructure Database, CiNii, Korean Medical Database, Korean Studies Information Service System, Oriental Medicine Advanced Searching Integrated System, ScienceOn. GRADE pro was used to evaluate the current evidence of the study. Result: A total of 5 studies, 325 women with DOR were included. EAHM showed a significant effect on improvement of pregnancy rate (n=270, RR 2.13 [95% CI 1.44 to 3.15], Z=3.78, p=0.0002, I2=0%) and Anti-Mullerian Hormone (AMH) level (n=211, SMD 0.82 [95% CI 0.40 to 1.25], Z=3.80, p=0.0001) compared to conventional medicine. In ovulation rate (n=156, RR 0.86 [95% CI 0.70 to 1.06], Z=1.43, p=0.15, I2=0%), Antral Follicle Count (n=245, SMD 0.27 [95% CI -0.25 to 0.79], Z=1.01, p=0.31), and follicle stimulating hormone (n=245, SMD 0.30 [95% CI -0.12 to 0.71], Z=1.40, p=0.16) level, EAHM showed similar effects to conventional medicine. In this study, the most frequently used herbal medicines were Cuscutae Semen, Dipsaci Radix, and Angelicae Gigantis Radix. Conclusion: This meta-analysis showed that EAHM could improve pregnancy rates and AMH levels in women with DOR. However, more well-designed RCTs will have to be performed further in the future.

keywords: Herbal Medicine, Ovarian Reserve, infertility, pregnancy rate, ovulation

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난소예비력 저하 여성에 대한 한약 단독 치료의 임신 관련 지표 개선 효과에 관한 체계적 문헌 고찰 및 메타분석

East Asian Herbal Medicine (EAHM) Alone for the Treatment of Women with Diminished Ovarian Reserve (DOR): A Systematic Review and Meta-analysis

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