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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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숙지황 추출물의 항염증 작용을 통한 항우울 효과

The Anti-depressive Effect of Rehmanniae Radix Preparata via Anti-inflammatory Activity

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2022, v.43 no.1, pp.99-111
김응선 (원광대학교 한의학전문대학원 제3의학과)
정명수 (원광대학교)
김응선, & 정명수. (2022). 숙지황 추출물의 항염증 작용을 통한 항우울 효과. 대한한의학회지, 43(1), 99-111.
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Abstract

Objectives: Rehmanniae Radix Preparata (RRP) has been used as a traditional remedy to treat gynecology and endocrine diseases. Recently, studies on antioxidant and anti-inflammatory effects of RRP have been reported, so it was judged that RRP extracts would have an anti-depressive effect. Methods: We investigated the anti-neuroinflammatory and anti-depressive effect of RRP on lipopolysaccharide (LPS)-induced depression and LPS-stimulated BV2 microglia. RRP inhibited the LPS-stimulated excessive release of nitrite in the BV2 cells. RRP also significantly inhibited the inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in LPS-stimulated BV2 microglial cells. Results: RRP significantly suppressed the LPS-induced mitogen-activated protein kinase (MAPKs) and nuclear factor (NF)-κB activation. In addition, administration of RRP not only inhibited the immobility time in the forced swimming test (FST) but also increased the total travel distance in the open field test (OFT). Also, RRP inhibited the elevation of TNF-alpha, IL-1beta, and IL-6 in brain of LPS-injected mice. Conclusions: Considering the overall results, our study showed that RRP exhibited the anti-neuroinflammatory and anti-depressive activities via deactivation of MAPKs and NF-κB.

keywords
Rehmanniae Radix Preparata (RRP), Anti-neuroinflammatory effect, Anti-depressive effect, inflammatory cytokine, Microglia cell


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