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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

정량적 자화율 맵핑을 통한 뇌 철분 침착과 파킨슨병의 연관성 분석

The Analysis of relation to brain iron deposition of Parkinson’s Disease using Quantitative Susceptibility Mapping

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2024, v.45 no.1, pp.148-162
전규리 (강동경희대학교병원)
이한결 (경희의료원 한방순환신경내과, 경희대학교 한의과대학 순환·신경내과)
권승원 (경희의료원 한방순환신경내과, 경희대학교 한의과대학 순환·신경내과)
조승연 (강동경희대학교병원 뇌신경센터 한방내과, 경희대학교 한의과대학 순환·신경내과)
정우상 (경희의료원 한방순환신경내과, 경희대학교 한의과대학 순환·신경내과)
문상관 (경희의료원 한방순환신경내과, 경희대학교 한의과대학 순환·신경내과)
박정미 (강동경희대학교병원 뇌신경센터 한방내과, 경희대학교 한의과대학 순환·신경내과)
고창남 (강동경희대학교병원 뇌신경센터 한방내과, 경희대학교 한의과대학 순환·신경내과)
박성욱 (강동경희대학교병원 뇌신경센터 한방내과, 경희대학교 한의과대학 순환·신경내과)
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Abstract

Objectives: This study aimed to investigate the levels of brain iron deposition in Parkinson's disease (PD) patients using Quantitative Susceptibility Mapping (QSM) and to determine whether distinctions compared to the general population exist. Furthermore, we examined potential variations in iron deposition among different PD subtypes. Methods: Structural brain imaging was conducted on 75 participants at Gangdong Kyung Hee University Hospital between August 2017 and May 2020. PD patients were categorized into Tremor Dominant (TD) and Postural Instability and Gait Difficulty (PIGD) subtypes. Voxel-based morphometry and QSM were employed to compare voxel-wise magnetic susceptibility across the entire brain between Normal Controls (NC) and PD groups. Subsequently, QSM values were compared between TD and PIGD groups. Results: QSM values were compared among 46 PD patients and 23 normal controls, as well as between TD (n=22) and PIGD (n=24) groups. Voxel-based QSM analysis revealed no significant differences between groups. Similarly, ROI-based QSM analysis showed no significant distinctions. Conclusions: No significant variations were observed between the PD patient group, NC group, or PD subtypes. This study systematically compared QSM values across a broad range of brain regions potentially linked to PD pathology. Additionally, the subdivision of the PD group into TD and PIGD subtypes for QSM-based iron deposition analysis represents a meaningful and innovative approach.

keywords
Parkinson’s disease, QSM, Brain, Iron, Subtype


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