- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
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Acute toxicity and genotoxicity assessment of Ligigeopoong-san
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2024, v.45 no.3, pp.40-53
Sung-Young,
C.
, Sung-Min,
H.
, Su-Yeong,
K.
, Jun-Sub,
K.
, Kyeong-Wan,
W.
, Hyun-Woo,
C.
, &
Jong-Hyun,
N.
(2024). Acute toxicity and genotoxicity assessment of Ligigeopoong-san. Journal of Korean Medicine, 45(3), 40-53.
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Abstract
Objectives: This study aimed to investigate whether Ligigeopoong-san induces acute toxicity and genotoxicity Methods: Ligigeopoong-san contains the rhizome of Cnidium officinale MAKINO, an herb with potential teratogenicity. Teratogenicity is closely associated with genotoxicity. We analyzed whether Ligigeopoong-san induces acute toxicity and genotoxicity using various experimental models in accordance with Korean non-clinical test standards for pharmaceuticals and OECD test guidelines. Results : When Ligigeopoong-san was administered as a single dose to male and female rats, no toxic reactions, including organ damage, were observed at doses up to 2,500 mg/kg. In the bacterial reverse mutation test, no DNA mutations were detected at concentrations up to 5,000 μg/plate. In cell models, Ligigeopoong-san did not induce structural or numerical chromosomal aberrations at concentrations up to 2,000 μg/mL. Additionally, in animal studies, it did not cause bone marrow toxicity or form micronuclei in erythrocytes at doses up to 2,000 mg/kg. Conclusions : The experiments using various models demonstrated that Ligigeopoong-san did not induce acute toxicity or genotoxicity.
- keywords
- Ligigeopoong-san, Acute toxicity, genotoxicity, Korean medicine, safety
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