This descriptive investigation aims to identify a relationship between QOL, depression, and anxiety in hemodialysis patients. I conducted this research on 130 subjects aged 19 or above who have received dialysis for at least one month in the hemodialysis unit at N hospital in the city of S. However, it came to 112 as I took out those who either quit, died, or filled out a questionnaire in the incorrect manner. In regards to average points of QOL on a 100-point scale, it is 57.77, demonstrating quite low QOL. Concerning average points of depression and anxiety, it is 12.25 and 10.52, respectively, showing quite a high figure. With regard to a correlation, there is a significant correlation between the three factors in hemodialysis patients: there is a negative correlation between QOL and depression (r=-.782, p<.001); a negative correlation between QOL and anxiety (r=-.719, p<.001); and a positive correlation between depression and anxiety (r=.873, p<.001). The outcome of multiple regression analysis on factors affecting QOL shows that depression is the element influencing QOL (β=-.585). Therefore, this study is significant in providing basic data for establishing intervention strategies aiming to reduce levels of depression which has the strongest impact on QOL in the patients and for developing a nursing intervention program intending to improve their QOL.