Purpose: This case study analyzed the cases of three patients who visited two Korean medical clinics to treat carpal tunnel syndrome, essential tremor, and eczema. Through this, we tried to advance the interpretation of Provision 159 of Shanghanlun. Methods: We analyzed how Jeokseokjiwooyeolyang-tang was taken in three cases and whether objective improvement occurred. Afterwards, we confirmed how the ‘利’ of Provision 159 was clinically expressed in the three cases and examined the correlation with the interpretation of ancient chinese. Results: The total duration of herbal medicine intake by case was 90 days for <Case 1> carpal tunnel syndrome patient, 150 days for <Case 2> essential tremor patient, and 240 days for <Case 3> eczema patient. All three patients showed improvement in their symptoms, did not show any side effects. The ‘利’ in Provision 159 is analyzed as symptoms such as increased frequency or amount of urination and abnormal uterine bleeding. These symptoms or situations are well compatible with the usage of Korean medicine. Conclusion: When prescribing Jeokseokjiwooyeolyang-tang in Provision 159, we need to consider situations such as abnormal diarrhea, increased frequency or amount of urination, and uterine bleeding.