- P-ISSN 2233-4203
- E-ISSN 2093-8950
- 권한신청
- P-ISSN2233-4203
- E-ISSN2093-8950
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Characterization of in vitro Metabolites of Methylenedioxy Designer Drugs
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2023, v.14 no.1, pp.1-8
https://doi.org/10.5478/MSL.2023.14.1.1
(Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
(Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
(College of Pharmacy, Sahmyook University)
(Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
(Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
(College of Pharmacy, Sahmyook University)
(Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University)
Yu,
J. S.,
Jo,
S. Y.,
Park,
I.,
Yoo,
H. H.,
&
(2023). . Mass Spectrometry Letters, 14(1), 1-8, https://doi.org/10.5478/MSL.2023.14.1.1
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Abstract
Eutylone, dibutylone, and dimethylone are potential psychotropic designer drugs. The purpose of this study was to investigate the in vitro metabolic pathways of synthetic cathinones with methylenedioxy groups. The three methylenedioxy derivatives were incubated with human liver microsomes. The metabolites were characterized based on liquid chromatography and quadrupole-time-of-flight mass spectrometry. Eutylone, dibutylone, and dimethylone were metabolized to yield three, six, and four metabolites, respectively. Reduction and demethylenation were the major metabolic pathways for all three drugs tested. However, dibutylone and dimethylone showed an additional metabolite generated via N-oxidation. These results provide evi- dence for the in vivo metabolism of methylenedioxy synthetic cathinones, and could be applied to the analysis of synthetic cathi- nones and their relevant metabolites in biological samples.
- keywords
- Methylenedioxy derivatives, Designer drug, Metabolism, LC/Q-TOF MS
- 투고일Submission Date
- 2023-02-10
- 수정일Revised Date
- 2023-03-04
- 게재확정일Accepted Date
- 2023-03-09
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