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- E-ISSN 2093-8950
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Rapid Surface Heating Promotes Laser Desorption Ionization of Thermally Labile Molecules from Surfaces
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2016, v.7 no.4, pp.91-95
https://doi.org/10.5478/MSL.2016.7.4.91
(Gachon University)
Han,
S.
Y.
(2016). Rapid Surface Heating Promotes Laser Desorption Ionization of Thermally Labile Molecules from Surfaces. Mass Spectrometry Letters, 7(4), 91-95, https://doi.org/10.5478/MSL.2016.7.4.91
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Abstract
In recent years, matrix-free laser desorption ionization (LDI) for mass spectrometry of thermally labile molecules has been an important research subject in the pursuit of new ionization methods to serve as alternatives to the conventional matrixassisted laser desorption ionization (MALDI) method. While many recent studies have reported successful LDI of thermally labile molecules from various surfaces, mostly from surfaces with nanostructures, understanding of what drives the LDI process still requires further study. This article briefly reviews the thermal aspects involved in the LDI mechanism, which can be characterized as rapid surface heating. The thermal mechanism was supported by observed LDI and postsource decay (PSD) of peptide ions produced from flat surfaces with special thermal properties including amorphous Si (a-Si) and tungsten silicide (WSix). In addition, the concept of rapid surface heating further suggests a practical strategy for the preparation of LDI sample plates, which allows us to choose various surface materials including crystalline Si (c-Si) and Au tailorable to specific applications.
- keywords
- Laser desorption ionization (LDI), Rapid surface heating, Thermal mechanism, Matrix-assisted laser desorption ionization (MALDI), Surface-assisted laser desorption ionization (SALDI)
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- Submission Date
- 2016-12-03
- Revised Date
- 2016-12-16
- Accepted Date
- 2016-12-19
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