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Tuberculosis & Respiratory Diseases

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Vol.56 No.6
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Short-term Clinical Experience on Interferon gamma-1b Therapy for Idiopathic Pulmonary Fibrosis

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2004, v.56 no.6, pp.619-627








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& (2004). Short-term Clinical Experience on Interferon gamma-1b Therapy for Idiopathic Pulmonary Fibrosis. Tuberculosis & Respiratory Diseases, 56(6), 619-627.
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Abstract

Background:Corticosteroids in combination with cytotoxic drugs are the mainstays of therapy for idiopathic pulmonary fibrosis (IPF). However, there has been no regimen showing any survival benefit. The aim of this study was to describe a short-term clinical experience on interferon gamma-1b (IFN-γ1b) therapy for IPF, as an antifibrotic agent.Methods:Medical records of 27 patients who were treated with IFN-γ1b (2 million IU, 3 times a week, subcutaneous injection) were retrospectively reviewed. Treatment response was assessed using ATS/ERS criteria in 17 patients who received IFN-γ1b for more than 6 months. In addition, we compared the efficacy of IFN-γ1b therapy with that of cyclophosphamide±prednisolone therapy (n=26).Results:The median age of IFN-γ treated group (M:F=19:8) was 59 years (44-74 years). Compared to the patients who showed a stable response at 6 months (n=12), the deteriorated group (n=5) had worse baseline lung function (FVC, 55.4±11.3% vs. 70.7±10.9%, p=0.019; DLco, 50.3±7.3% vs. 76.9±19.6%, p=0.014). Lower baseline PaO2 on room air breathing was observed in the deteriorated group (68.6±7.8mmHg vs. 91.4±6.6mmHg p=0.001). Subcutaneous IFN-γ1b did not show better efficacy than prednisolone. Five patients discontinued IFN-γ because of severe side effects. ARDS developed in one patient, who eventually died. Conclusion:The administration of IFN-γ1b is not desirable for patients diagnosed with IPF with poor lung function. Long-term and large-scaled clinical studies are needed for its efficacy in IPF.(Tuberculosis and Respiratory Diseases 2004, 56:619-627)

keywords
Pulmonary fibrosis, Usual interstitial pneumonia

Reference

1.

(2000) Idiopathic pulꠀmonary Fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS) and the European Respiratory Society (ERS) ,

2.

(1999) NHLBI Workshop Summary. Pharmacological therapy for idiopathic pulꠀmonary fibrosis. Past, present, and future,

3.

(1998) Idiopathic pulꠀmonary fibrosis: clinical relevance of pathoꠀlogic classification,

4.

(1998) Idiopathic pulmonary fibrosis: current concepts,

5.

(1998) Cyclophosphamide pulse therapy in idiopathic pulmonary fibrosis,

6.

(chest1993) Outcome of subjects with idiopathic pulꠀ Implications for further studies,

7.

(2000) Cycloꠀphosphamide in the treatment of idiopathic pulmonary fibrosis: a prospective study in patients who failed to respond to corticoꠀsteroids,

8.

(1995) Increased expression of type VI collagen in lung fibrosis,

9.

(2001) Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and impliꠀcations for therapy,

10.

(2001) Idiopathic pulꠀmonary fibrosis,

11.

(1997) Adenovector-mediated gene tranꠀsfer of active transforming growth factor- beta1 induces prolonged severe fibrosis in rat lung,

12.

(1990) Cytokine networks in the regulation of inflammation and fibrosis in the lung,

13.

(1999) A preliminary study of long- term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis,

14.

(1998) Fishman？s Pulmonary Disease and Disorders, McGraw- Hill

15.

(radiology1989) correlation of extent of disease at CT with clinical,

16.

(2003) 통상성 간질성 폐렴과 비특이성 간질성 폐렴의 치료에 있어 Cyclophosphamide의 역할,

17.

(2003) Comparison of Interferon Gamma-1b and Colchicine in the Treatment of Idiopathic Pulmonary Fibrosis: Interim Results of a Prospective, Multicenter Randomized Study,

18.

(2004) A placebo-controlled trial of interferon gamma- 1b in patients with idiopathic pulmonary fibrosis,

19.

(2003) Acute respiratory failure after interferon- gamma therapy of end-stage pulmonary fibrosis,

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