Background : Paclitaxel is highly beneficial anticancer drug for the treatment of non-small cell lung cancer and has shown remarkable radiosensitizing effect in vitro. We evaluated whether concurrent chemoradiation therapy with weekly paclitaxel (60 mg/m2) could be tolerated and effective in the treatment of locally advanced non-small cell lung cancer (NSCLC). Methods : Twenty-two stage III (IIIA:6, IIIB:16) NSCLC patients were treated with weekly administration of paclitaxel (60 mg/m2) on days 1, 8, 15, 22, 29, and 36 in addition to concurrent radiation therapy of 54 Gy. After the initial phase of concurrent chemoradiation, patients received additional two cycles of consolidation chemotherapy with paclitaxel (175mg/m2)/cisplatin (75 mg/m2) or paclitaxel (175 mg/m2)/carboplatin (6AUC) every 3 weeks. Results : Overall response rate was 81.8% (18/22) with 9.1% (2/22) of complete response and 72.7% (16/22) of partial response rate. Two patients (9.1%) died of chemoradiation-induced pneumonitis after completion of therapy. In total, grade 3 toxicities included pneumonitis (22.7%), esophagitis (22.7%), neuropathy (13.6%), and neutropenia (13.6%). The median survival time was 15 months and 2-year overall survival were 31.8%. Conclusion : Concurrent chemoradiation therapy with weekly paclitaxel in locally advanced NSCLC showed good local response, but survival rate was not completely satisfactory due to potentially fatal chemoradiation-induced pneumonitis.(Tuberc Respir Dis 2004; 57:351-357)
(1981) Etiologic consideration in superior vena cava syndrome,
(1985) Clinical study on superior vena cava syndrome,
(1949) Obstruction of the superior vena cava:a review of the literature and report of two personal cases,
(1954) The superior vena cava syndrome,
(1966) Superior vena caval syndrome due to tuberculosis.Report of three cases,
(2000) Superior vena cava syndrome during the treatment of pulmonary tuberculosis in an HIV-1 infected patient,
(1988) The roentgenololgic findings of tuberculous mediastinal lymphadenitis,
(1978) Tuberculous mediastinal lymphadenitis in the adult,
(1974) Superior mediastinal mass:secondary to tuberculous lymphadenitis in the adult,
(1995) Chest CT findings and clinical features in mediastinal tuberculous lymphadenitis,
(1999) Clinical features in primary mediastinal tuberculous lymphadenitis,
(1986) Low attenuation thoracic metastases in testicular malignancy,
(1986) Intrathoracic manifestation of lymphoma,
(1994) Sudden enlargement of a deep cervical lymph node during and after treatment for pulmonary tuberculosis,