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Tuberculosis & Respiratory Diseases

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Vol.57 No.5
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Activity of Moxifloxacin Against Ofloxacin-Resistant Mycobacterium Tuberculosis: A Study of Cross-Resistance Between Ofloxacin and Moxifloxacin

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2004, v.57 no.5, pp.405-410



& (2004). Activity of Moxifloxacin Against Ofloxacin-Resistant Mycobacterium Tuberculosis: A Study of Cross-Resistance Between Ofloxacin and Moxifloxacin. Tuberculosis & Respiratory Diseases, 57(5), 405-410.
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Abstract

Background : Moxifloxacin is an 8-methoxyquinolone compound which has been shown to have the best activity of the quinolones against M. tuberculosis but there is no literature showing the rate of cross-resistance between moxifloxacin and the other quinolones such as ofloxacin. Therefore, we tested the activity of moxifloxacin against ofloxacin resistant M. tuberculosis by a study of cross-resistance. Methods : We tested MIC's of moxifloxacin and ofloxacin by proportion method against 34 M. tuberculosis isolates showing resistance against ofloxacin at 2.5㎍/㎖ concentration and 13 ofloxacin susceptible isolates from specimens submitted to clinical laboratory of National Masan Hospital from March 2003 to March 2004. Results : For ofloxacin susceptible isolates, MIC50 and MIC90 of ofloxacin were all 1.25㎍/㎖, and MIC50 and MIC90 of moxifloxacin were 0.31㎍/㎖ and 0.63㎍/㎖ respectively. For ofloxacin resistant isolates, MIC50 of ofloxacin was over 10㎍/㎖ and MIC50 of moxifloxacin was 5㎍/㎖ ,MIC90 of ofloxacin and moxifloxacin were all over 10㎍/㎖. The rate of cross-resistance between the two was 67.6%(23/34) at 2.5㎍/㎖ concentration. Conclusions : Moxifloxacin showed activity against 82.4%(28/34) of ofloxacin resistant M. tuberculosis at 10㎍/㎖, but more studies are needed so that moxifloxacin will be used for patient with multi-drug resistant tuberculosis including oflokacin resistance.(Tuberc Respir Dis 2004; 57:405-410)

keywords
Moxifloxacin, Ofloxacin, Quinolone, Cross-resistance, Tuberculosis.Ofloxacin 내성 마이코박테리아에 대한 Moxifloxacin의 항결핵 효과: Ofloxacin과 Moxifloxacin의 교차내성 연구를 중심으로국립마산병원 임상연구소김병주, 강영수, 박승규Activity of Moxifloxacin Against Ofloxacin-Resistant Mycobacterium Tuber, Moxifloxacin, Ofloxacin, Quinolone, Cross-resistance, Tuberculosis.Ofloxacin 내성 마이코박테리아에 대한 Moxifloxacin의 항결핵 효과: Ofloxacin과 Moxifloxacin의 교차내성 연구를 중심으로국립마산병원 임상연구소김병주, 강영수, 박승규Activity of Moxifloxacin Against Ofloxacin-Resistant Mycobacterium Tuber

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