Adjuvant Chemotherapy after Surgical Resection for Small-Cell Carcinoma of Lung

Background : Small-cell carcinomas of lung have a tendency for rapid growth and early wide metastasis. Despite the high response rates of combination chemotherapy alone or with radiotherapy, the overall long-term survival rate is very disappointing. According to autopsy findings, the common cause of failure is local recurrence in the primary cancer site. Therefore, surgical resection with combined chemotherapy has recently been attempted for very early stage small-cell carcinomas of the lung. Methods : 10 patients (TNM I & II: 5 cases each) undergoing surgical resection for small-cell carcinomas of the lung were treated with adjuvant chemotherapy in an attempt to prolong survival. Of these, 9 patients received chemotherapy, and a retrospective study for survival undertaken (Kaplan-Meier analysis). Results : The median survival time was 26 months, and the 2- and 5-year survival rates were 68.6 and 46.7%, respectively. If the 1 patient not having undergone chemotherapy was excluded, the 2-, 5-year survival rates were 76.2 and 50.8%, respectively? No difference in the survival rate was seen between patients with TNM stages Ⅰ and Ⅱ. Conclusion : Adjuvant chemotherapy after surgical resection results in prolonged survival for patients with TNM stages I and II small-cell carcinomas of the lung. (Tuberc Respir Dis 2004; 57:443-448)

keywords: Small-cell lung carcinoma, Operation, Chemotherapy, Survival.소세포폐암에서 수술 후 복합화학요법의 성적원광대학교 의과대학 내과학교실김학렬, 정종훈, 김휘정, 양세훈, 정은택Adjuvant Chemotherapy after Surgical Resection for Small-Cell Carcinoma of LungHak-Ryul Kim, M.D., Jong-Hoon Jung, M.D., Hwi-J, Small-cell lung carcinoma, Operation, Chemotherapy, Survival.소세포폐암에서 수술 후 복합화학요법의 성적원광대학교 의과대학 내과학교실김학렬, 정종훈, 김휘정, 양세훈, 정은택Adjuvant Chemotherapy after Surgical Resection for Small-Cell Carcinoma of LungHak-Ryul Kim, M.D., Jong-Hoon Jung, M.D., Hwi-J

Reference

(1978) Staging procedures and prognostic features in small cell anaplastic bronchogenic carcinoma,

(1995) Small cell cancer. State-of-the art therapy 1994,

(1987) Metastatic patterns in small-cell lung cancer:correlation of autopsy findings with clinical parameters in 537 patients,

(1992) A meta-analysis of thoracic radiotherapy for small-cell lung cancer,

(1991) Surgical treatment for limited small- cell lung cancer.The University of Toronto Lung Oncology Group experience,

(1973) Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus.Ten-year follow-up,

(1980) Pre-operative radiotherapy and surgery in the treatment of oat cell carcinoma of the bronchus,

(1979) Medical Research Coucil Lung Working Party,

(1977) Adjuvant cancer chemotherapy after resection of carcinoma of the lung,

10.

(1982) Surgical resection in the management of small cell carcinoma of the lung,

11.

(thoraccardiovascsurg1986) Small cell carcinoma of the lung to operate or not,

12.

(eurjcardiothoracsurg1991) Multimodality treatment for small cell bronchial carcinoma Prelinary results of a prospeatire, multicenter trial

13.

(1987) Surgery after initial chemotherapy for localized small-cell carcinoma of the lung,

14.

(1989) A prospective study of adjuvant surgical resection after chemotherapy for limited small cell lung cancer.A University of Toronto Lung Oncology Group study,

15.

(1991) Influence of surgical resection before and after chemotherapy on survival in small cell lung cancer,

16.

(1987) Postchemotherapy resection of residual tumor in limited stage small cell lung cancer,

17.

(1983) The prognostic significance of histopathologic subtyping of small cell carcinoma of the lung according to the classification of the World Health Organization.A study of 375 consecutive patients,

18.

(1983) Reduction in local recurrence and improved survival in surgically treated patients with small cell lung cancer,

19.

(1988) Adjuvant chemotherapy following surgical resection for small-cell carcinoma of the lung,

20.

(1991) Surgery plus adjuvant chemotherapy for T1-3N0M0 small-cell lung cancer.Rationale for current approach,

21.

(1993) A prospective analysis of chemotherapy following surgical resection of clinical stage I-II small-cell lung cancer,

바로가기메뉴

Article Contents

Vol.57 No.5

Adjuvant Chemotherapy after Surgical Resection for Small-Cell Carcinoma of Lung

Abstract

Reference

Tuberculosis & Respiratory Diseases