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Tuberculosis & Respiratory Diseases

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Vol.58 No.2
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Nuclear Factor-κB(NF-κB) Activity and Levels of IL-6, IL-8 and TNF-αin Induced Sputum in the Exacerbation and Recovery of COPD atients

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2005, v.58 no.2, pp.152-159








& (2005). Nuclear Factor-κB(NF-κB) Activity and Levels of IL-6, IL-8 and TNF-αin Induced Sputum in the Exacerbation and Recovery of COPD atients. Tuberculosis & Respiratory Diseases, 58(2), 152-159.
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Abstract

Background : Exacerbations of chronic obstructive pulmonary disease (COPD) are thought to be associated with increased airway inflammation, and the NF-κB is known to be an indicator of cellular activation and of inflammatory mediator production. This study was undertaken to investigate the change of cytokine characteristics and NF-kB activity in induced sputum of COPD patients during exacerbation and recovery of the disease.Methods : Sputum induction was performed in 37 patients with COPD during exacerbation and during recovery and in 15 healthy subjects. Cell counts, levels of IL-6, IL-8 and TNF-α in induced sputum and NF-kB activity in macrophage of induced sputum were measured.Results : Patients with COPD showed significantly increased levels of IL-6, IL-8 and TNF-α(p<0.01) and increased NF-kB activity in induced sputum(p<0.05) as compared with control subjects. Level of IL-8 during exacerbation of COPD decreased significantly during recovery(p<0.05). NF-kB activity and levels of IL-6 and TNF-α tended to be decreased during recovery, but not siginificantly. Conclusion : Activation of NF-kB and increased levels of IL-6, IL-8 and TNF-α were thought to be associated with pathogenesis and exacerbations of COPD. (Tuberc Respir Dis 2005; 58:152-159)

keywords
COPD, exacerbation, NF-kB, IL-6, IL-8, TNF-α

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