바로가기메뉴

본문 바로가기 주메뉴 바로가기

Tuberculosis & Respiratory Diseases

Article Contents

Prev Next
e-Submission

Vol.60 No.2
Citation Share

Predictors of Long-term Mortality after Hospitalization for Acute Exacerbation of COPD

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2006, v.60 no.2, pp.205-214





& (2006). Predictors of Long-term Mortality after Hospitalization for Acute Exacerbation of COPD. Tuberculosis & Respiratory Diseases, 60(2), 205-214.
  • Downloaded
  • Viewed
PDF Download

Abstract

Background : Acute exacerbations form a major component of the socioeconomic burden of COPD. As yet, little information is available about the long-term outcome of patients who have been hospitalized with acute exacerbations, although high mortality rates have been reported. The aim of this study was to determine predictors of long-term mortality after hospitalization for acute exacerbation of COPD.Methods : We performed a retrospective cohort study of consecutive patients admitted to the hospital for COPD exacerbation between 2000 through 2004. Patients who had died in hospital or within 6-months after discharge, had tuberculosis scar, pleural thickening or bronchiectasis by chest radiography or had been diagnosed with malignancy during follow-up periods were excluded.Results : Mean age of patients was 69.5 years, mean follow-up duration was 49 months, and mean FEV1 was 1.00L (46% of predicted). Mortality was 35% (17/48). In the multivariate Cox regression analysis, heart rate of 100/min or more (p=0.003; relative risk [RR], 11.99; 95% confidence interval [CI], 2.34-61.44) and right ventricular systolic pressure (RVSP) of 35mmHg or more (p=0.019; RR, 6.85; 95% CI, 1.38-34.02) were independent predictors of mortality.Conclusion : Heart rate and RVSP in stable state may be useful in predicting long-term mortality for COPD patients admitted to hospital with acute exacerbation.(Tuberc Respir Dis 2006; 60: 205-214)

keywords
COPD, Mortality determinants, Heart rate, Right ventricular systolic pressure, COPD, Mortality determinants, Heart rate, Right ventricular systolic pressure

Reference

1.

(2002) COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity.,

2.

(2003) Acute exacerbation of chronic obstructive pulmonary disease,

3.

(2003) In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease,

4.

(2002) Mortality after hospitalization for COPD,

5.

(1986) Prognosis in chronic obstructive pulmonary disease,

6.

(1996) Outcomes following acute exacerbation of severe chronic obstructive lung disease Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments,

7.

(2003) Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD,

8.

(1999) Reversible and irreversible airflow obstruction as predictors of overall mortality in asthma and chronic obstructive pulmonary disease,

9.

(1979) Predictors of mortality in chronic obstructive pulmonary disease:a 15-year follow-up study,

10.

(1985) APACH II:a severity of disease classification system,

11.

(2005) In-hospital and 5-year mortality of patients treated in the ICU for acute exacerbation of COPD:a retrospective study,

12.

(2003) APACHE II predicts long-term survival in COPD patients admitted to a general medical ward,

13.

(2001) Predictors of outcome for patients with COPD requiring invasive mechanical ventilation,

14.

(1995) Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease,

15.

(2005September) Standards for the diagnosis and management of patients with COPD, American Thoracic Society

16.

(2001) Global strategy for the diagnosis and prevention of chronic obstructive pulmonary disease NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease(GOLD) Workshop summary,

17.

(1995) Standardization of spirometry:1994 update,

18.

(2005) Feigenbaum's echocardiography, Lippincott Williams & Wilkins

19.

(1995) Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease,

20.

(1994) Predictors of survival in subjects with chronic obstructive pulmonary disease treated with long-term oxygen therapy,

21.

(1991) Predictors of survival in patients with chronic obstructive pulmonary disease treated with long-term oxygen therapy,

22.

(1990) Survival in chronic obstructive pulmonary disease after diagnosis of pulmonary hypertension related to long-term oxygen therapy,

23.

(2000) Left atrial and ventricular filling in chronic obstructive pulmonary disease:an echocardiography and doppler study,

24.

(2005) Post-exercise heart rate recovery and mortality in chronic obstructive pulmonary disease,

25.

(1969) Prediction of survival in patients with chronic airway obstruction,

26.

(1999) Prognostic value of nutritional status in chronic obstructive pulmonary disease,

27.

(2004) The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease.,

28.

(2003) Prognostic value of nutritional depletion in patients with COPD treated by long-term oxygen therapy:data from the ANTADIR observatory,

29.

(2005) Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease,

30.

(2001) Dose dependent increased mortality risk in COPD patients treated with oral glucocorticoids,

Tuberculosis & Respiratory Diseases

e-Submission OA Policy