바로가기메뉴

본문 바로가기 주메뉴 바로가기

Tuberculosis & Respiratory Diseases

Article Contents

Prev Next
e-Submission

Vol.60 No.3
Citation Share

The Correlation between the Radiological Changes and the Level of Transforming Growth Factor-β1 in Patients with Pulmonary Tuberculosis

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2006, v.60 no.3, pp.297-303





& (2006). The Correlation between the Radiological Changes and the Level of Transforming Growth Factor-β1 in Patients with Pulmonary Tuberculosis. Tuberculosis & Respiratory Diseases, 60(3), 297-303.
  • Downloaded
  • Viewed
PDF Download

Abstract

Background : Pulmonary tuberculosis is frequently accompanied with complications such as bronchiectasis, cavities, fibrosis and a deterioration of the lung function. However, there is little information available on the pathogenesis of these complications in pulmonary tuberculosis. Among the many factors involving in tissue remodeling, transforming growth factor-β1 (TGF-β1) is a potent stimulus of the extracellular matrix fomation and a mediator of potential relevance for airway wall remodeling. Therefore, this study examined the relationship between the radiological changes and the TGF-β1 level in patients with pulmonary tuberculosis.Methods : Serum and bronchoalveolar lavage fluid (BALF) were collected from total of 35 patients before treating them for active pulmonary tuberculosis, and the TGF-β1 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The BALF levels were recalculated as the epithelial lining fluid (ELF) levels using the albumin method. pulmonary function test (PFT) and high resolution computed tomography (HRCT) were performed before and after treatment.Results : There was a strong correlation between the serum TGF-β1 level and the presence of cavities (r=0.404, p=0.006), even though the BAL TGF-β1 level showed a weak correlation with complications. In addition, there was no correlation between the TGF-β1 levels before treatment and the changes in the PFT and HRCT during treatment.Conclusion : There is a correlation between the serum TGF-β1 level and cavity formation in pulmonary tuberculosis before treatment. However, further study will be needed to confirm this.(Tuberc Respir Dis 2006; 60: 297-303)

keywords
Pulmonary tuberculosis, TGF-β1, Cavity, High resolution computed tomography, Pulmonary tuberculosis, TGF-β1, Cavity, High resolution computed tomography

Reference

1.

Tuberculosis in developing countries,

2.

(2000) Role of transforming growth factor beta in human disease,

3.

(1990) The transforming growth factor-β family,

4.

(1994) Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a)mice,

5.

(1994) Transforming growth factor beta in tissue fibrosis,

6.

(1989) Subepithelial fibrosis in the bronchi of asthmatics,

7.

(2005) Post-treatment changes of six cytokines in active pulmonary tuberculosis:differences between patients with stable or increased fibrosis,

8.

(1999) Cytokine levels correlate with a radiologic score in active pulmonary tuberculosis,

9.

(2005) The correlation between bronchostenosis and changes in the levels of interferon-γ and transforming growth factor-β during the treatment in patients with endobronchial tuberculosis,

10.

(2003) Circulating cytokine levels and changes during the treatment in patients with active tuberculosis in Korea,

11.

(2006) Impact of circulating TGF-β and IL-10 on T cell cytokines in patients with asthma and tuberculosis,

12.

(1986) Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution,

13.

(1995) Global epidemiology of tuberculosis:morbidity and mortality of a worldwide epidemic,

14.

(2004) Increased expression of mRNA encoding interleukin -4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis in the absence of in vitro stimulation,

15.

(2004) IL-10 down-regulates costimulatory molecules on Mycobacterium tuberculosis-pulsed macrophages and impairs the lytic activity of CD4 and CD8 CTL in tuberculosis patients,

16.

(2004) Morphometric analysis of Th cytokine expression in human pulmonary tuberculosis,

17.

(1994) Enhancement of intracellular growth of Mycobacterium tuberculosis in human monocytes by transforming growth factor-β,

18.

(1995) Enhanced production of TGFβ by blood monocytes from patients with active tuberculosis and presence of TGFβ in tuberculous granulomatous lung lesions,

19.

(1996) Pulmonary immune response to Mycobacterium tuberculosis and human immunodeficiency virus,

20.

(1993) Pulmonary tuberculosis:CT findings-early active disease and sequential change with antituberculous therapy,

21.

(1986) Centrilobular lesions of the lung:demonstration by high-resolution CT and pathologic correlation,

22.

(2005) The roles of HRCT and clinical parameters in assessing activity of suspected smear negative pulmonary tuberculosis,

23.

(2004) Presence and HRCT quantification of bronchiectasis in coal workers,

24.

(2003) The high value of high-resolution computed tomography in predicting the activity of pulmonary tuberculosis,

25.

(2002) Correlation of immunologic status with high-resolution CT and distributions of pulmonary tuberculosis,

Tuberculosis & Respiratory Diseases

e-Submission OA Policy