A Case of Behcet's Disease with Multiple Cavitary Lung Lesion

Behcet’s disease is a systemic vasculitis of an unknown etiology involving the arteries and veins of all sizes. There are reports showing that a pulmonary artery aneurysm or thromboembolism and superior vena cava thrombosis are present in 5-10% of patients with Behcet's disease and that lung parenchymal lesions are mainly airway consolidations resulting from hemorrhage or infarction. We encountered a patient with increasing pulmonary cavitary changes and localized aspergilloma. The patient was a 43-year-old man diagnosed with Behcet’s disease with a history of recurrent oro-genital ulceration and uveitis, and who was administered methotrexate, colchicines, prednisolone. During the follow up he developed progressive dyspnea upon exertion and finger clubbing. Therefore further evaluations were performed. Chest computed tomography showed more advanced consolidations and cavitations than the previous film with the previously known aspergilloma still observable. An open lung biopsy was carried out to determine the presence of malignant changes, which revealed nonspecific vasculitis. Azathioprine was added resultion in an improvement of symptoms.(Tuberc Respir Dis 2006; 61: 65-69)

keywords: Behcet’s disease, Cavitary lung lesion, Aspergilloma., Behcet’s disease, Cavitary lung lesion, Aspergilloma.

Reference

Sakane T,, (1999) Behcet’s disease,

Jegal YJ,, (2000) A case of Behcet’s disease with pulmonary infarction,

Raz I, Chajek-Shaul T. Pulmonary manifestations in Behcet’s syndrome. Chest 1989,

Kim YJ,, (2004) A case of Behcet’s disese with superior vena cava syndrome.,

Erkan F,, (2001) Pulmonary manifestation of Behcet’s disease,

Park KJ, (1996) Clinical manifestations of the lung involvement in Behcet’s syndrome.,

Kim HS, (2002) A case of suspected Behcet’s disease diagnosed by manifestation of pulmonary artery aneurysm.,

Yoo DH, (1989) A case of Behcet’s disease with pulmonary arteritis manifestaed as multiple pulmonary nodules.,

Aydintug AO, et al. Antibodies to endotherlial cells in patients with Behcet’s disease. Clin Immunol Immunopathol 1993,

10.

Haznedaroglu IC,, (1998) Haemostasis, thrombosis, and endothelium in Behcet’s disease,

11.

Cervera R, et al. Antibodies to endothelial cells in Behcet’s disease cell-binding heterogeneity and association with clinical activity. Ann Rheum Dis 1994,

12.

Han SW, (2003) Cardiovascular involvement in Behcet’s disease.,

13.

Pollak ES, (1998) Endothelial cells in physiology and in the pathophysiology of vascular disorders.,

14.

Broze GJ Jr, (1995) Tissue factor pathway inhibitor and the current concept of blood coagulation.,

15.

Greenberger PA, Diagnosis and management of allergic bronchopulmonary aspergillosis.,

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Article Contents

Vol.61 No.1

A Case of Behcet's Disease with Multiple Cavitary Lung Lesion

Abstract

Reference

Tuberculosis & Respiratory Diseases