Cognitive Dysfunction in non-hypoxemic COPD Patients

Background: The cognitive function is impaired in patients with hypoxemic chronic obstructive pulmonary disease (COPD). However, there are conflicting results regarding the cognitive function in patients with non-hypoxemic COPD. COPD patients also have sleep disorders. This study examined the cognitive function in non-hypoxemic COPD patients, and nocturnal sleep was assessed in COPD patients with a cognitive dysfunction. Methods: Twenty-eight COPD patients (mean age, 70.7 years) with an oxygen saturation > 90%, and 33 healthy control subjects (mean age, 69.5 years) who had visited for a routine check-up were selected. The neurocognitive tests were performed using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) Neuropsychological Battery. Results: The scores of the word list recall test (p=0.03) and the word list recognition test (p=0.006) in the COPD group were significantly lower than those in the control group. Nine patients showed a significantly impaired cognitive function. Seven of these underwent polysomnography, which revealed apnea-hypopnea indices ≥ five per hour in five patients. The median oxygen desaturation index and median limb movement index were 3.6/h and 38.6/h, respectively. Conclusion: These results suggest that the verbal memory function is impaired in non-hypoxemic COPD patients. Six out of seven COPD patients with an impaired cognitive function had sleep disorders of sleep apnea and/or periodic limb movements during sleep. (Tuberc Respir Dis 2007; 62: 382-388)

keywords: Chronic obstructive pulmonary disease, Cognitive function, Sleep disorders., Chronic obstructive pulmonary disease, Cognitive function, Sleep disorders.

Reference

(1973) Neuropsychologic effects of continuous oxygen therapy in chronic obstructive pulmonary disease,

(1982) Neuropsychologic findings in hypoxemic chronic obstructive pulmonary disease,

(1983) Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease,

Etnier J, (1999) The relationships among pulmonary function, aerobic fitness, and cognitive functioning in older COPD patients,

Incalzi RA, (1997) Verbal memory impairment in. COPD: its mechanisms and clinical relevance,

(2004) Cognitive performance in patients with COPD,

(2003) Cognitive impairment in chronic obstructive pulmonary disease:a neuropsychological and spect study,

(2002) Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction,

(2000) Impact of sleep in COPD,

10.

(2000) Cognitive deficits associated with sleep apnea syndrome:a proposed neuropsychological test battery,

11.

(1991) A new method for measuring daytime sleepiness:the Epworth sleepiness scale,

12.

(2002) Development of the Korean version of the Consortium to Establish a Registry for Alzheimer’s disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries,

13.

(2001) Cerebral metabolic abnormalities in COPD patients detected by localized proton magnetic resonance spectroscopy,

14.

(2004) Frontal brain lobe impairment in obstructive sleep apnoea:a proton MR spectroscopy study,

15.

(1997) Treatment of nocturnal airway obstruction improves daytime cognitive performance in asthmatics,

16.

(2003) Sleep disorders in the elderly with and without chronic airflow obstruction:the SARA study,

17.

(2003) Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease,

18.

(2001) Changes in cognitive function associated with sleep disordered breathing in older people,

19.

(1995) Neuropsychological function in obstructive sleep apnea syndrome compared to chronic obstructive pulmonary disease (COPD),

20.

(2002) Systemic effects in COPD,

21.

(2006) C-reactive protein in patients with COPD, control smokers and non- smokers,

22.

(2005) Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systemic review and meta-analysis,

23.

(2005) Childhood IQ, smoking and cognitive change from age 11 to 64 years,

바로가기메뉴

Article Contents

Vol.62 No.5

Cognitive Dysfunction in non-hypoxemic COPD Patients

Abstract

Reference

Tuberculosis & Respiratory Diseases