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Relations between Polymorphism of NRAMP1 Gene and Susceptibility to Pulmonary Tuberculosis
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Abstract
Background: Several lines of evidence suggest that a host's genetic factors influence the outcome of exposure to Mycobacterium tuberculosis. The aim of this study was to determine whether polymorphism in NRAMP1 (natural resistance associated macrophage protein 1) gene is associated with the susceptibility or resistance to tuberculosis infection for patients with drug-sensitive pulmonary tuberculosis (DS-TB) and multi-drug resistant pulmonary tuberculosis (MDR-TB). Methods: Eight genetic polymorphisms of the NRAMP1 gene were investigated in patients suffering with DS-TB (n=100) or MDR-TB (n=102), and in healthy normal controls (NC, n=96). The genetic polymorphisms of NRAMP1 were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequency of D543N A/G heterogygotes was significantly higher in the DS-TB subjects than the NCs (OR=2.10, 95% CI: 1.00 to 4.41, p=0.049). The frequency of 823C/T T/C heterozygotes was significantly higher in the DS-TB subjects (OR=2.79, 95% CI: 1.11 to 7.04, p=0.029) and the MDR-TB subject (OR=3.30, 95% CI 1.33 to 8.18, p=0.010) than in the NCs. However, the frequency of these genotypes was not different between the DS-TB and MDR-TB subjects. Conclusion: A significant association was found between NRAMP1 823 C/T polymorphism and pulmonary tuberculosis. This result suggests that NRAMP1 polymorphism may be involved in the development of pulmonary tuberculosis in Koreans. (Tuberc Respir Dis 2007; 62: 492-498)
- keywords
- NRAMP1, Polymorphism, Tuberculosis., NRAMP1, Polymorphism, Tuberculosis.
Reference
(2004) A century of tuberculosis,
Tuberculosis in developing countries,
(1998) Genetic susceptibility to tuberculosis in human populations,
(2001) Genetics of susceptibility to infectious diseases:tuberculosis and leprosy as examples,
(1990) Immunogenetics of mycobacterial infections:mouse- human homologies,
(1976) Genetics of resistance to infection with Salmonella typhimurium in mice,
(1991) Genetic regulation of macrophage priming/activation:the Lsh gene story,
(1993) Natural resistance to infection with intracellular parasites:isolation of a candidate for Bcg,
(1995) Identification of polymorphism and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene,
(1998) Variations in the NRAMP1 gene and susceptibility to tuberculosis in west africans,
(2005) Association of HLA-DR and HLA-DQ genes with susceptibility to pulmonary tuberculosis in Koreans:preliminary evidence of associations with drug resistance,disease severity,and disease recurrence,
(1996) Polymerase chain reaction-based sequence- specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis:relevance to chemotherapy and disease severity,
(2000) Molecular subtypes of the HLA-DR antigens in pulmonary tuberculosis,
(2003) Clinical and genetic risk factors for the development of multi-drug resistant tuberculosis in non-HIV infected patients at a tertiary care center in India:a case-control study,
(1978) Tuberculosis in twins:a re-analysis of the Prophit survey,
(1942) Twin studies on the significance of genetic factors in tuberculosis,
(1990) Racial differences in susceptibility to infection by Mycobacterium tuberculosis,
(1997) Differential induction of apoptosis by virulent Mycobacterium Tuberculosis in resistant and susceptible murine macrophage,
(1997) The effect of Bcg gene on antigen presentation of spleen adherent cells and peritoneal macrophages from Mycobacterium bovis BCG-infected Bcgs and Bcgr mice,
(1997) Natural resistance to infection with intracellular parasites:The Nramp1 protein is recruited to the membrane of the phagosome,
(1999) Genetic regulation of macrophage activation: understanding the function of NRAMP1(=Ity/Lsh/Bcg),
(1998) Macrophage NRAMP1 and its role in resistance to microbial infections,
(1999) Mycobacterium tuberculosis phagosome,
(1997) Evidence that genetic susceptibility to Mycobacterium tuberculosis in an Brazilian population is under oligogenic control:linkage study of the candidate gene NRAMP1 and TNFA,
(1998) Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil,
(1998) Analyses of the NRAMP1 and IFN-γ R1 genes in women with Mycobacterium avium- intracellulare pulmonary disease,
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