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A Comparison of Conventional Cytology and ThinPrep Cytology of Bronchial Washing Fluid in the Diagnosis of Lung Cancer
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Abstract
Background: A ThinPrep?? Processor was developed to overcome the limitations of conventional cytology and is widely used to diagnose various cancers. This study compared the diagnostic efficacy of conventional cytology for lung cancer with that of the ThinPrep?? cytology using the bronchial washing fluid. Methods: The bronchial washing fluid of 790 patients from Jan. 2002 to Dec. 2006, who were suspected of gaving a lung malignancy, was evaluated. Both ThinPrep?? and conventional cytology were performed for all specimens. Result: Four hundred forty-six men and 344 women were enrolled in this study, and 197 of them were diagnosed with cancer from either a bronchoscopic biopsy or a percutaneous needle aspiration biopsy. ThinPrep?? cytology showed a sensitivity, specificity, positive predictive value, negative predictive value and false negative error rate of 71.1%, 98.0%, 92.1%, 91.1%, 8.9%, respectively. The conventional cytology showed sensitivity, specificity, positive predictive value, nagative predictive value and false negative error rate of 57.9%, 98.0%, 90.5%, 87.5%, 12.5%, respectively. For central lesions, the sensitivity of conventional cytology and ThinPrep?? were 70.1% and 82.8%, respectively. Conclusion: ThinPrep?? cytology showed a higher sensitivity and lower false negative error rate than conventional cytology. This result was unaffected by the histological classification of lung cancer. Therefore, ThinPrep?? cytology appears to be a useful method for increasing the detection rate of lung cancer in bronchial washing cytology test. (Tuberc Respir Dis 2007; 62: 523-530)
- keywords
- Lung cancer, Bronchial washing, ThinPrep, Conventional cytology., Lung cancer, Bronchial washing, ThinPrep, Conventional cytology.
Reference
(2007) Cancer statistics, 2007,
(2002) Epidemiology of lung cancer in Korea,
(1998) Recent advances in thin-layer Cytology,
(1996) Nongynecologic cytology utilizing the ThinPrep Processor,
(2001) The new World Health Organization classification of lung tumours,
(2000) Thin-layer technology:tempered enthusiasm,
(1995) Comparison of conventional and ThinPrep preparations of mucoid cytology samples,
(1997) Comparison of ThinPrep and conventional preparations:non-gynecologic evaluation,
(2006) Comparison of Thinprep (liquid-based cytology) and conventional cytology: abnormal lesion on bronchoscopy,
(2000) Exfoliative cytology of primary poorly differentiated (small-cell) neuroendocrine carcinoma of the uterine cervix in Thin-Prep material: a case report,
(2000) Interpretation of fine-needle aspirates processed by the ThinPrep technique:cytologic artifacts diagnostic pitfalls,
(actacytol1990) Diagnostic value of crush artifact in cytologic specimens Occurrence in small cell carcinoma of the lung,
(2001) A comparative study:conventional preparation and ThinPrep 2000 in respiratory cytology,
(2003) Performance characteristics of different modalities for diagnosis of suspected lung cancer,
(actacytol1993) Comparative study of nongynecologic processing by ThinPrep vs rationale for the use of ThinPrep,
(1996) Immunocytochemical staining on ThinPrep processed smears,
(chest1986) Survival and mortality from lung cancer in a screened population,
(1986) Lung cancer screening:the Mayo program,
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