바로가기메뉴

본문 바로가기 주메뉴 바로가기

Prognostication by Cluster Analysis of COX-2, MMP-9 and P53 Expresion and by Clinico-pathologic Correlation Analysis in Non-small Cell Lung Cancer

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2007, v.63 no.1, pp.31-41




  • Downloaded
  • Viewed

Abstract

Background: In pathogenesis and prognosis of lung cancer, significance of enormous types of genetic expression were very compounding and undetermined. We performed this study to search association between clinical characteristics and expression of COX-2, MMP-9 and p53 in non-small cell lung cancer. Methods: Ninety-one patients with adenocarcinoma or squamous cell carcinoma were enrolled. We had searched clinical data retrospectively and performed immunohistochemical staining for COX-2, MMP-9 and p53. We had analyzed significance of these three genes in clinical features and prognosis for survival. Results: 1) In squamous cell carcinoma, male was predominant and was significantly correlated with smoking. 2) Major prognostic determinants for overall survival were curative resection. 3) Expression of COX-2 was more frequent in adenocarcinoma than in squamous cell carcinoma. 4) Negative staining of COX-2, MMP-9 and p53 was more frequent in squamous cell carcinoma than adenocarcinoma. 5)  Survival duration was longer in the group with positive expression of p53 and negative for COX-2 and MMP-9 (median duration of survival = 165.6 weeks) than groups with the other expressional patterns. 6) Significant correlation was found between expression of MMP-9 and COX-2. In squamous cell carcinoma, expression of MMP-9, COX-2 and mutant p53 were mutually correlated. 7) COX-2 expression was significant prognostic factor for survival in resected cancer group. In unresected inoperable non-small cell lung cancer group, MMP-9 was statistically significant prognostic factor for overall survival. Conclusion: COX-2 and MMP-9 might have some roles for progression or prognosis in some selected patients with non-small cell lung cancer. COX-2 and MMP-9 may have some roles for disease progression or prognosis in selected patients with NSCLC. (Tuberc Respir Dis 2007; 63: 31-41)

keywords
COX-2, MMP-9, P53, Non-small cell lung cancer., COX-2, MMP-9, P53, Non-small cell lung cancer.

Reference

1.

(2005) Global cancer statistics, 2002,

2.

(1998) Genetic instabilities in human cancers,

3.

(1951-4.) et al. Detection of chromosomal polysomy in oral leukoplakia,

4.

(1999) Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation,

5.

(2001) The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis ,

6.

(2001) Genetic instability in epithelial tissues at risk for cancer,

7.

Sidransky D. Microsatellite alterations as clonal markers for the detection of human cacner. Proc Natl Acad Sci U S A 1994,

8.

(1997) Prognostic value of replication errors on chromosomes 2p and 3p in non-small cell lung cancer,

9.

(1996) Fractional allele loss data indicate distinct genetic populations in the development of non-small cell lung cancer,

10.

(1997) Reduced survival in patients with stage-I non-small-cell lung cancer associated with DNA-replication errors ,

11.

(1999) Sequential molecular abnormalities are involved in the multistage development of squamous cell carcinoma,

12.

(2000) Prognostic implications of microsatellite alteration profiles in early-stage non-small cell lung cancer,

13.

(1996) Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients,

14.

Smejkal W. Field cancerization in oral stratified squamous epithelium clinical implications of multicentric origin. Cancer 1953,

15.

(2001) Long-term impact of smoking on lung epithelial proliferation in current and former smokers,

16.

(1999) Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation,

17.

(1999) Cyclooxygenase-2 expression in hepatocellular carcinoma,

18.

(1998) COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer,

19.

(1999) Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer : a population-based study,

20.

DuBois RN. Upregualtion of cyclooxygenase 2 gene expression human colorectal adenomas and adenocarcinomas. Gastroenterology 1994,

21.

(1995) Expression of cyclooxygenase-1 and -2 in human colorectal cancer,

22.

(2004) Multifaceted roles of cyclooxygenase-2 in lung cancer,

23.

(2003) Control of apoptosis by p53,

24.

(2003) p53 and regulation of DNA damage recognition during nucleotide excision repair,

25.

(2002) p53 regulation of DNA excision repair pathways,

26.

(2003) Clinical value of p53, c-erbB2, CEA and CA125 regrding relapse, metastasis and death in resectable non-small cell-lung cancer,

27.

(2003) Expression of p53, pRB, and p16 in lung tumors: a validation study on tissue microarrays,

28.

(1998) Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: clinical implications,

29.

(2001) Molecular biologic markers and micrometastasis in resected non-small cell lung cancer,

30.

(1999) Correlation of abnormal p16INK4A and p53 expression with 3p loss of heterozygosity and clinical features in 103 primary non-small cell lung cancers,

31.

(2003) P53 and Bcl-2 protein expression and its relationship with prognosis in small-cell lung cancer,

32.

(1999) Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer,

33.

(1999) Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms,

34.

(2006) Cyclooxygenase-2 expression in squamous cell carcinoma of the oral cavity and pharynx: association to p53 and clinical outcome,

35.

(2005) Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer,

36.

(2001) Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer,

37.

(2004) Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer,

38.

(2004) Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment,

39.

(2004) COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung,

40.

(2003) Morphometric evaluation of tumor matrix metalloproteinase 9 predicts survival after surgical resection of adenocarcinoma of the lung,

Tuberculosis & Respiratory Diseases