바로가기메뉴

본문 바로가기 주메뉴 바로가기

Correlation Between NT-proBNP and Pulmonary arterial Pressure in COPD Patients

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2007, v.63 no.4, pp.346-352








  • Downloaded
  • Viewed

Abstract

Background: Pulmonary hypertension is one of the cardiovascular complications of in COPD. However, a diagnosis of pulmonary hypertension requires an invasive test, such as right heart catheterization. NT-proBNP is a cardiac hormone that is elevated when a cardiac volume or pressure overload is present. It was hypothesized that NT-proBNP might play a role in detecting of pulmonary hypertension in COPD patients. Method: The 31 COPD patients, who underwent all of NT-proBNP, echocardiography, and spirometry in Seoul National University Bundang Hospital during the period from November 2003 to July 2005, were retrospectively analyzed. Result: Of the 31 COPD patients, 9 patients had pulmonary hypertension. A significant positive correlation was observed between the NT-proBNP and pulmonary arterial pressure (r=0.589, p=0.002). However, there was no significant correlation observed between the FEV1 and NT-proBNP and FEV1 and pulmonary arterial pressure. Conclusion: NT-proBNP might indicate the presence of pulmonary hypertension in COPD patients. (Tuberc Respir Dis 2007; 63: 346-352)

keywords
Chronic obstructive pulmonary disease, Pulmonary hypertension, Natriuretic peptide, NT-proBNP., Chronic obstructive pulmonary disease, Pulmonary hypertension, Natriuretic peptide, NT-proBNP.

Reference

1.

National Heart, Lung, and Blood Institute and World Health Organization, (revised2006) Global initiative for chronic obstructive lung disease: global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

2.

Kim DS, (2005) Prevalence of chronic obstructive pulmonary disease in Korea,

3.

Agusti AG, (2003) Systemic effects of chronic obstructive pulmonary disease,

4.

Higenbottam T. , (2005) Pulmonary hypertension and chronic obstructive pulmonary disease: a case for treatment,

5.

Naeije R, (2005) Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease,

6.

Barbera JA, (2003) Pulmonary hypertension in chronic obstructive pulmonary disease,

7.

Naeije R, (2001) Pulmonary hypertension associated with COPD,

8.

Weitzenblum E, (2005) Severe pulmonary hypertension in COPD: is it a distinct disease? ,

9.

Lee-Chiong Jr TL, (2003) Pulmonary hypertension and cor pulmonale in COPD,

10.

Arcasoy SM, (2003) Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease ,

11.

Kessler R, (2001) "Natural history" of pulmonary hypertension in a series of 131 patients with chronic obstructive lung disease,

12.

Bossone E, (2005) Pulmonary arterial hypertension: the key role of echocardiography,

13.

Kim NH, (2004) Diagnosis and evaluation of patient with pulmonary hypertension,

14.

Yap LB, (2004) Natriuretic peptides, respiratory disease, and right heart,

15.

Ruskoaho H, (2003) Caridac hormones as diagnostic tools in heart failure,

16.

Clerico A, (2004) Diagnostic accuracy and prognostic relavance of measurement of cardiac natriuretic peptides: a review,

17.

McQuillan BM, (2001) Clinical correlates and reference intervals for pulmonary arterial systolic pressure among echocardiographically normal subjects,

18.

Barst RJ, (2004) Diagnosis and differential assessment of pulmonary arterial hypertension,

19.

Voelkel NF, (2003) Pulmonary vascular involvement in chronic obstructive pulmonary disease,

20.

(2005) Severe pulmoanry hypertension and chronic obstructive pulmonary disease.,

21.

(2002) National Emphysema Treatment Trial (NETT) Research Group. Hemodynamic characterization of patients with severe emphysema,

22.

The clinical and physiological difference of chronic bronchitis and emphysema. Am J Med Sci 1964, Vincent TN

23.

Litt BD. The Veterans Administration cooperative study of pulmonary function 3. Mortality in relation to respiratory function in chronic obstructive pulmonary disease. Am J Med 1966,

24.

(2000) Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension,

25.

(1999) Elevated plasma brain natriuretic peptide levels in chronic respiratory failure with cor pulmonale,

26.

(2000) Plasma concentration of brain natriuretic peptide as a biochemical marker for evaluation of right ventricular overload and mortality in chronic respiratory disease,

27.

(1998) Plasma brain natiruretic peptide levels increase in proportion to extent of right ventricular dysfunction in pulmonary hypertension,

28.

(2003) Prognostic value of high plasma brain natriuretic peptide concentrations in very elderly persons,

Tuberculosis & Respiratory Diseases