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Vol.64 No.2
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Clinical Usefulness and the Accuracy of Korean Reference Equation for Diffusing Capacity

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2008, v.64 no.2, pp.80-86












& (2008). Clinical Usefulness and the Accuracy of Korean Reference Equation for Diffusing Capacity. Tuberculosis & Respiratory Diseases, 64(2), 80-86.
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Abstract

Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park's equation) with that of the foreign equation (Burrows' equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows' equation and Park's equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows' equation and Park's equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows' equation and Park's equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows' equation and 78% for the use of Park's equation. The sensitivity and specificity of the Burrows' equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park's equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park's equation for diagnosing ILD was significantly higher than that of Burrows' equation (p＜0.001). Conclusion: The Korean reference equation (Park's equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows' equation).

keywords
Diffusing capacity, Reference equations, Clinical usefulness, Accuracy

Reference

1.

Gold WM. Chapter 24. Pulmonary function testing. In: Mason RJ, Broaddus VC, Murray JF, Nadel JA, editors. Murray and Nadel's textbook of respiratory medicine. 4th ed. Philadelphia: Elsevier Saunders; 2005. p. 695-703.

2.

Knudson RJ, Kaltenborn WT, Burrows B. The effects of cigarette smoking and smoking cessation on the carbon monoxide diffusing capacity of the lung in asymptomatic subjects. Am Rev Respir Dis 1989;140:645-51.

3.

Neas LM, Schwartz J. The determinants of pulmonary diffusing capacity in a national sample of U.S. adults. Am J Respir Crit Care Med 1996;153:656-64.

4.

Yang TS, Peat J, Keena V, Donnelly P, Unger W, Woolcock A. A review of the racial differences in the lung function of normal Caucasian, Chinese and Indian subjects. Eur Respir J 1991;4:872-80.

5.

Park JO, Choi IS, Park KO. Normal predicted standards of single breath carbon monoxide diffusing capacity of lung in healthy nonsmoking adults. Korean J Med 1985;28:176-83.

6.

Burrows B, Kasik JE, Niden AH, Barclay WR. Clinical usefulness of the single-breath pulmonary diffusing capacity test. Am Rev Respir Dis 1961;84:789-806.

7.

Quanjer PH. Standardized of lung function testing. Report working party. Bull Eur Physiopathol Respir 1983;19 Suppl 5:1-95.

8.

Crapo RO, Morris AH. Standardized single breath normal values for carbon monoxide diffusing capacity. Am Rev Respir Dis 1981;123:185-9.

9.

Paoletti P, Viegi G, Pistelli G, Di Pede F, Fazzi P, Polato R, et al. Reference equations for the single-breath diffusing capacity. A cross-sectional analysis and effect of body size and age. Am Rev Respir Dis 1985;132:806-13.

10.

Roca J, Rodriguez-Roisin R, Cobo E, Burgos F, Perez J, Clausen JL. Single-breath carbon monoxide diffusing capacity prediction equations from a Mediterranean population. Am Rev Respir Dis 1990;141:1026-32.

11.

Song EH, Oh YM, Hong SB, Shim TS, Lim CM, Lee SD, et al. Selection of reference equations for lung volumes and diffusing capacity in Korea. Tuberc Respir Dis 2006;61:218-26.

12.

Stocks J, Quanjer PH. Reference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory Society. Eur Respir J 1995;8:492-506.

13.

American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995;152: 1107-36.

14.

Cotes JE. Lung function. 1st ed. Oxford: Blackwell scientific publications; 1975.

15.

Crapo RO, Forster RE 2nd. Carbon monoxide diffusing capacity. Clin Chest Med 1989;10:187-98.

16.

Weisell RC. Body mass index as an indicator of obesity. Asia Pac J Clin Nutr 2002;11 Suppl 8:681-4.

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