바로가기메뉴

본문 바로가기 주메뉴 바로가기

Tuberculosis & Respiratory Diseases

Article Contents

Prev Next
e-Submission

Vol.64 No.4
Citation Share

Successful Treatment of Mycobacterium fortuitum Lung Disease with Oral Antibiotic Therapy: a Case Report

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2008, v.64 no.4, pp.293-297






& (2008). Successful Treatment of Mycobacterium fortuitum Lung Disease with Oral Antibiotic Therapy: a Case Report. Tuberculosis & Respiratory Diseases, 64(4), 293-297.
  • Downloaded
  • Viewed
PDF Download

Abstract

Mycobacterium fortuitum usually causes colonization or transient infection in patients with underlying lung disease,such as prior tuberculosis or bronchiectasis. The majority of these patients may not need to receive antibiotic therapy for M. fortuitum isolates. We report here on a patient with M. fortuitum lung disease and who was successfully treated with combination oral antibiotic therapy. A 53-year-old woman was referred to our institution because of purulent sputum and dyspnea. A chest radiograph and computed tomography scan revealed cavitary consolidation in the left upper lobe and multiple small cavities in the left lower lobe. Numerous acid-fast bacilli (AFB) were seen in multiple sputum specimens and M. fortuitum was identified by culture from the sputum specimens. The patient received antibiotic treatment including clarithromycin, ciprofloxacin and sulfamethoxazole, because her symptoms were worsening despite conservative treatment. Sputum conversion was achieved after one month of antibiotic therapy. Both the patient's symptoms and radiographic findings improved after 10 months of antibiotic therapy.

keywords
Mycobacterium fortuitum, Atypical mycobacteria, Lung disease

Reference

1.

1. Wolinsky E. Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis 1979;119:107-59.

2.

2. Brown TH. The rapidly growing mycobacteria- Mycobacterium fortuitum and Mycobacterium chelonei.Infect Control 1985;6:283-8.

3.

3. Wallace RJ Jr, Swenson JM, Silcox VA, Good RC,Tschen JA, Stone MS. Spectrum of disease due to rapidly growing mycobacteria. Rev Infect Dis 1983;5:657-79.4. Koh WJ, Kwon OJ, Jeon K, Kim TS, Lee KS, Park YK,et al. Clinical significance of nontuberculous mycobacteria isolated from respiratory specimens in Korea.Chest 2006;129:341-8.

4.

5. Awe RJ, Gangadharam PR, Jenkins DE. Clinical significance of Mycobacterium fortuitum infections in pulmonary disease. Am Rev Respir Dis 1973;108:1230-4.

5.

6. Griffith DE, Girard WM, Wallace RJ Jr. Clinical features of pulmonary disease caused by rapidly growing mycobacteria:an analysis of 154 patients. Am Rev Respir Dis1993;147:1271-8.

6.

7. Park S, Suh GY, Chung MP, Kim H, Kwon OJ, Lee KS,et al. Clinical significance of Mycobacterium fortuitum isolated from respiratory specimens. Respir Med 2008;102:437-42.

7.

8. Lee SM, Kim J, Jeong J, Park YK, Bai GH, Lee EY, et al. Evaluation of the broth microdilution method using 2, 3-diphenyl-5-thienyl-(2)-tetrazolium chloride for rapidly growing mycobacteria susceptibility testing. J Korean Med Sci 2007;22:784-90.

8.

9. Daley CL, Griffith DE. Pulmonary disease caused by rapidly growing mycobacteria. Clin Chest Med 2002;23:623-32, vii.

9.

10. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A,Daley C, Gordin F, et al. An official ATS/IDSA statement:diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007;175:367-416.

10.

11. Brown-Elliott BA, Wallace RJ Jr. Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria. Clin Microbiol Rev2002;15:716-46.

11.

12. Vadakekalam J, Ward MJ. Mycobacterium fortuitum lung abscess treated with ciprofloxacin. Thorax 1991;46:737-8.

12.

13. Tasaka S, Urano T, Mori M, Yamaguchi K, Kanazawa M. A case of Mycobacterium fortuitum pulmonary disease in a healthy young woman successfully treated with ciprofloxacin and doxycycline. Kekkaku 1995;70:31-5.

13.

14. Ichiyama S, Tsukamura M. Ofloxacin and the treatment of pulmonary disease due to Mycobacterium fortuitum.Chest 1987;92:1110-2.

14.

15. American Thoracic Society statement: diagnosis and treatment of disease caused by nontuberculous mycobacteria.Am J Respir Crit Care Med 1997;156:S1-25.

15.

16. Kim SJ, Hong YP, Bai GH, Kim SC, Jin BW. Nontuberculous pulmonary infection in two patients with Mycobacterium avium-intracellulare complex and a patient with M. fortuitum. J Korean Soc Microbiol 1982;17:87-93.

Tuberculosis & Respiratory Diseases

e-Submission OA Policy