Prognostic Significance of Fascin Expression in Stage I Non-small Cell Lung Cancer

Background: Fascin is an actin-bundling protein that plays an important role in cellular motility. Fascin is normally expressed in the neuronal and mesenchymal cells and its expression is low or absent in the epithelia. However, an overexpression of fascin has been linked to the invasive behavior of some neoplasms such as breast, stomach and ovarian tumors. In this study, we evaluated the expression of fascin and its prognostic significance in stage I non-small cell lung cancer (NSCLC). Methods: Immunohistochemical staining for fascin was performed on the paraffin-embeded tissue sections of 81 cases of resected NSCLC. Staining of more than 5% of the tumor cells was recorded as positive immunoreactivity. Results: Fascin expression was seen in 73% (59/81) of the cases and this was more frequently seen in squamous cell carcinoma than in adenocarcinoma (93% vs 42%). There were no significant correlations of fascin immunoreactivity with tumor recurrence and overall survival. Conclusion: The expression rate of fascin was relatively high in NSCLC, but this was without prognostic significance. The exact clinical role of fascin should be defined through further investigations.

keywords: Fascin, Lung cancer, Prognosis

Reference

1.Minna JD. Chapter 75. Neoplasms of the lung. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison's principles of internal medicine. 16th ed. New York: McGraw-Hill Co, Inc.; 2005. p. 506-15.

2.Hilsenbeck SG, Raub WA Jr, Sridhar KS. Prognostic factors in lung cancer based on multivariate analysis. Am J Clin Oncol 1993;16:301-9.

3.Mountain CF. New prognostic factors in lung cancer. biologic prophets of cancer cell aggression. Chest 1995; 108:246-54.

4.Zhu CQ, Shih W, Ling CH, Tsao MS. Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation. J Clin Pathol 2006;59:790-800.

5.Niklinski J, Niklinska W, Laudanski J, Chyczewska E, Chyczewski L. Prognostic molecular markers in non-small cell lung cancer. Lung Cancer 2001;34:S53-8.

6.Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006;12:895-904.

7.Carragher NO, Frame MC. Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol 2004;14:241-9.

8.Kureishy N, Sapountzi V, Prag S, Anikumar N, Adams JC. Fascins, and their roles in cell structure and function. Bioessays 2002;24:350-61.

9.Yamashiro S, Yamakita Y, Ono S, Matsumura F. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell 1998;9:993-1006.

10.

10.Hashimoto Y, Shimada Y, Kawamura J, Yamasaki S, Imamura M. The prognostic relevance of fascin expression in human gastric carcinoma. Oncology 2004; 67:262-70.

11.

11.Yoder BJ, Tso E, Skacel M, Pettay J, Tarr S, Budd T, et al. The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course. Clin Cancer Res 2005;11:186-92.

12.

12.Hashimoto Y, Skacel M, Adams JC. Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? Int J Biochem Cell Biol 2005;37: 1787-804.

13.

13.Choi PJ, Yang DK, Son CH, Lee KE, Lee JI, Roh MS. Fascin immunoreactivity for preoperatively predicting lymph node metastases in peripheral adenocarcinoma of the lung 3 cm or less in diameter. Eur J Cardiothorac Surg 2006;30:538-42.

14.

14.Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, et al. Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. Br J Cancer 2003;88:537-47.

15.

15.Bryan J, Edwards R, Matsudaira P, Otto J, Wulfkuhle J. Fascin, an echinoid actin-bundling protein, is a homolog of Drosophila singed gene product. Proc Natl Acad Sci U S A 1993;90:9115-9.

16.

16.Hu W, McCrea PD, Deavers M, Kavanagh JJ, Kudelka AP, Verschraegen CF. Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors. Clin Exp Metastasis 2000;18:83-8.

바로가기메뉴

Article Contents

Vol.65 No.2

Prognostic Significance of Fascin Expression in Stage I Non-small Cell Lung Cancer

Abstract

Reference

Tuberculosis & Respiratory Diseases