바로가기메뉴

본문 바로가기 주메뉴 바로가기

Tuberculosis & Respiratory Diseases

Article Contents

Prev Next
e-Submission

Vol.65 No.3
Citation Share

A Case of Extensive Stage Small Cell Lung Cancer Presenting as an Acute Appendicitis with Perforation

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2008, v.65 no.3, pp.230-234











& (2008). A Case of Extensive Stage Small Cell Lung Cancer Presenting as an Acute Appendicitis with Perforation. Tuberculosis & Respiratory Diseases, 65(3), 230-234.
  • Downloaded
  • Viewed
PDF Download

Abstract

The incidence of appendiceal metastatic cancer is quite low. In particular, in small cell lung cancer, there is a very low incidence of a metastasis to the appendix. A 75-years old man with right lower quadrant pain, cough and sputum was transferred to our hospital. Abdominal CT revealed acute appendicitis with a perforation. The patient underwent surgery. The frozen sections of the tissue obtained during surgery, indicated a malignancy, but a right hemicolectomy was not performed due to the patient’s poor general condition. The histology findings of the appendix were identified as a small cell carcinoma. The abdominal CT scan and chest x-ray at admission day showed a mass in the right lower lobe, and a further evaluation of the lesion was performed including positron emission tomography and flexible bronchoscopy with a biopsy. The pathology findings of the lung mass were also small cell lung cancer. The specimens from both sites stained positive for cytokeratin, cluster designation 56, synaptophysin, chromogranin-A and thyroid transcription factor 1. It was concluded that the appendiceal small cell cancer originated from the lung.

keywords
Appendix, Metastasis, Small cell carcinoma

Reference

1.

1. Cohen MH, Matthews MJ. Small cell bronchogenic carcinoma: a distinct clinicopathologic entity. Semin Oncol 1978;5:234-43.

2.

2. Sridhar KS, Hussein AM, Thurer RJ. Evolving role of surgical treatment in limited-disease small cell lung carcinoma. J Surg Oncol 1989;40:155-61.

3.

3. Johnson BE. Management of small cell lung cancer. Clin Chest Med 2002;23:225-39.

4.

4. Pang LC. Metastasis-induced acute appendicitis in small cell bronchogenic carcinoma. South Med J 1988;81:1461-2.

5.

5. Goldstein EB, Savel RH, Walter KL, Rankin LF, Satheesan R, Lehman HE, et al. Extensive stage small cell lung cancer presenting as an acute perforated appendix: case report and review of the literature. Am Surg 2004;70:706-9.

6.

6. Levchenko AM, Vasechko VN, Erusalimskiĭ EL. Metastasis of small-cell lung cancer to the appendix. Klin Khir 1985;5:56-7.

7.

7. Park IJ, Yu CS, Kim HC, Kim JC. Clinical features and prognostic factors in primary adenocarcinoma of the appendix. Korean J Gastroenterol 2004;43:29-34.

8.

8. Cortina R, McCormick J, Kolm P, Perry RR. Management and prognosis of adenocarcinoma of the appendix. Dis Colon Rectum 1995;38:848-52.

9.

9. Ryo H, Sakai H, Ikeda T, Hibino S, Goto I, Yoneda S, et al. Gastrointestinal metastasis from lung cancer. Nihon Kyobu Shikkan Gakkai Zasshi 1996;34:968-72.

10.

10. Lobins R, Floyd J. Small cell carcinoma of unknown primary. Semin Oncol 2007;34:39-42.

11.

11. Lau SK, Luthringer DJ, Eisen RN. Thyroid transcription factor-1: a review. Appl Immunohistochem Mol Morphol 2002;10:97-102.

12.

12. Ordonez NG. Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas. Am J Surg Pathol 2000;24:1217-23.

13.

13. Fletcher MS. Gastric perforation secondary to metastatic carcinoma of the lung: a case report. Cancer 1980;46:1879-82.

14.

14. Morgan MW, Sigel B, Wolcott MW. Perforation of a metastatic carcinoma of the jejunum after cancer chemotherapy. Surgery 1961;49:687-9.

15.

15. Shen YY, Shiau YC, Wang JJ, Ho ST, Kao CH. Whole-body 18F-2-deoxyglucose positron emission tomography in primary staging small cell lung cancer. Anticancer Res 2002;22:1257-64.

Tuberculosis & Respiratory Diseases

e-Submission OA Policy