바로가기메뉴

본문 바로가기 주메뉴 바로가기

Tuberculosis & Respiratory Diseases

Article Contents

Prev Next
e-Submission

Vol.65 No.5
Citation Share

Improvement of Pulmonary Function after Administration of Azithromycin in a Patient with Bronchiolitis Obliterans: a Case Report

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2008, v.65 no.5, pp.410-415








& (2008). Improvement of Pulmonary Function after Administration of Azithromycin in a Patient with Bronchiolitis Obliterans: a Case Report. Tuberculosis & Respiratory Diseases, 65(5), 410-415.
  • Downloaded
  • Viewed
PDF Download

Abstract

Bronchiolitis obliterans (BO) is a serious noninfectious complication following an allogeneic bone marrow transplant (BMT). A 21-year-old female received an allogeneic BMT as a treatment for myelodyplastic syndrome. Four months after the BMT, progressive dyspnea developed and BO was also diagnosed by a lung biopsy. The patient was administered steroid and immunosuppressive agents for 1 year but there was no improvement in pulmonary function. Azithromycin was prescribed (500 mg q.d. for 3 days followed by 250 mg three time a week) because macrolides might decrease the inflammatory reaction leading to BO. The patient’s pulmonary function improved after administration of azithromycin for 1 year. The forced expiratory volume in a one second (FEV1) increase was 220 mL (28.2%) and the forced vital capacity (FVC) increase was 460 mL (25.7%). We report the improvement in the pulmonary function after the administration of azithromycin for 1 year in a patient with BO after a BMT.

keywords
Bone marrow transplantation, Bronchiolitis obliterans, Pulmonary function, Azithromycin

Reference

1.

Roca J, (1982) Fatal airway disease in an adult with chronic graft-versus-host disease, Thorax

2.

Soubani AO, (2007) Bronchiolitis obliterans following haematopoietic stem cell transplantation, Eur Respir J

3.

Marras TK, (2003) Obliterative bronchiolitis complicating bone marrow transplantation, Semin Respir Crit Care Med

4.

Khalid M, (2005) Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study, Eur Respir J

5.

Katzenstein AL, (2006) Chap 16. Miscellaneous II. Nonspecific inflammatory and destructive diseases. In Surgical pathology of non-neoplastic lung disease, Saunders

6.

Kim CJ, (1998) Bronchiolitis obliterans and generalized vitiligo as rare presentations of chronic graft-versus-host disease, Korean J Pediatr Hematol-Oncol

7.

Afessa B, (2001) Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation, Bone Marrow Transplant

8.

Corrin B, (2006) Chapter 3. Diseases of the airways. In Pathophysiology of the lungs, Churchill Livingstone

9.

Sakaida E, (2003) Late-onset noninfectious pulmonary complications after allogeneic stem cell transplantation are significantly associated with chronic graft-versus-host disease and with the graft-versus-leukemia effect, Blood

10.

Au WY, (2001) Respiratory ciliary function in bone marrow recipients, Bone Marrow Transplant

11.

Ringden O, (1999) Increased risk of chronic graft-versus- host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia, Blood

12.

Gerhardt SG, (2003) Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study, Am J Respir Crit Care Med

13.

Bashoura L, (2008) Inhaled corticosteroids stabilize constrictive bronchiolitis after hematopoietic stem cell transplantation, Bone Marrow Transplant

14.

Tamaoki J, (2004) The effects of macrolides on inflammatory cells, Chest

Tuberculosis & Respiratory Diseases

e-Submission OA Policy