A Case of Hypersensitivity Pneumonitis in an Automobile Paint Sprayer

Hypersensitivity pneumonitis (HP) is an immunologically-mediated disease resulting from repeated exposure to sensitizing agents, such as organic dusts or chemicals. Isocyanate is a volatile and highly reactive chemical that is extensively used in the manufacturing of automobiles, upholstery, and polyurethane foam. Occupational respiratory diseases associated with isocyanate, such as bronchial asthma, are well-known. It is thought that HP is one of the rare diseases induced by isocyanate with a very low frequency worldwide. We report a case of HP in an automobile painting sprayer which appeared to be associated with isocyanate

keywords: Hypersensitivity pneumonitis, Isocyanate, Paint sprayer

Reference

1. Selman M. Hypersensitivity pneumonitis. In: Schwarz MI, King TE Jr, editors. Interstitial lung disease. 3rd ed. Hamilton, BC: Decker; 1998. p. 393-422.

2. Glazer C, Rose CS. Hypersensitivity pneumonitis. In: Resenstock L, Cullen MR, Brodkin CA, Redlich CA, editors. Textbook of clinical occupational and environmental medicine. 2nd ed. Philadelphia: Elsevier Saunders; 2005. p. 346-56.

3. Butcher BT, Salvaggio JE, O'Neil CE, Weill H, Garg O. Toluene diisocyanate pulmonary disease: immunopharmacologic and mecholyl challenge studies. J Allergy Clin Immunol 1977;59:223-7.

4. Coultas DB, Zumwalt RE, Black WC, Sobonya RE. The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med 1994;150:967-72.

5. Vandenplas O, Malo JL, Dugas M, Cartier A, Desjardins A, Levesque J, et al. Hypersensitivity pneumonitis-like reaction among workers exposed to diphenylmethane diisocyanate (MDI). Am Rev Respir Dis 1993;147:338-46.

6. Baur X. Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. J Allergy Clin Immunol 1995;95;1004-10.

7. Bernstein IL. Isocyanate-induced pulmonary diseases: a current perspective. J Allergy Clin Immunol 1982;70:24-31.

8. NIOSH Criteria Documents Criteria for a recommended standard for a toluene diisocyanate standard and occupational exposure to toluene diisocyanate.[database on the Internet] Bethesda (MD): National Institute of Occupational Safety and Health (US); c1973 [updated 2007 Apr 25; cited 2007 May 22]. Available from: http://www.cdc.gov/niosh/73-11023.html

9. Kim GT, Choo WS, Park SU, Kim DG, Jeong GS, Nam SH. Hypersensitivity pneumonitis by Isocyanate. Tuberc Respir Dis 1991;38:483.

10.

10. Cecile S. Chapter 62. Hypersensitivity pneumonitis. In: Mason R, Murray J, Broaddus V, Nadel J, editors. Murray and Nadel's textbook of respiratory medicine. 4th ed. Philadelphia: Elsevier Saunders; 2005. p. 1783-99.

11.

11. Schuyler M, Cormier Y. The diagnosis of hypersensitivity Pneumonitis. Chest 1997;111:534-6.

바로가기메뉴

Article Contents

Vol.65 No.6

A Case of Hypersensitivity Pneumonitis in an Automobile Paint Sprayer

Abstract

Reference

Tuberculosis & Respiratory Diseases