The stomach is a rare site for metastasis, with autopsy incidence rates of 0.2% to 1.7%. This low rate makes diagnosis of metastatic gastric cancer challenging for clinicians. The authors report a case of a 64-year-old man diagnosed with gastric metastasis of primary lung adenocarcinoma that was initially mistaken for primary gastric cancer, as well as a review of the medical literature.
Kadakia SC, Parker A, Canales L. Metastatic tumors to the upper gastrointestinal tract: endoscopic experience. Am J Gastroenterol 1992;87:1418-23.
Menuck LS, Amberg JR. Metastatic disease involving the stomach. Am J Dig Dis 1975;20:903-13.
Wu MH, Lin MT, Lee PH. Clinicopathological study of gastric metastases. World J Surg 2007;31:132-6.
Green LK. Hematogenous metastases to the stomach: a review of 67 cases. Cancer 1990;65:1596-600.
Oda, Kondo H, Yamao T, Saito D, Ono H, Gotoda T, et al. Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy 2001;33:507-10.
Hsu CC, Chen JJ, Changchien CS. Endoscopic features of metastatic tumors in the upper gastrointestinal tract. Endoscopy 1996;28:249-53.
Campoli PM, Ejima FH, Cardoso DM, Silva OQ, Santana Filho JB, Queiroz Barreto PA, et al. Metastatic cancer to the stomach. Gastric Cancer 2006;9:19-25.
Kim HS, Jang WI, Hong HS, Lee CI, Lee DK, Yong SJ, et al. Metastatic involvement of the stomach secondary to lung carcinoma. J Korean Med Sci 1993;8:24-9.
Kim HG, Kim YS, Choi SD, Won YJ, Jung JH, Sue YB, et al. A case of squamous cell lung cancer with metastasis of the stomach. Korean J Gastrointest Endosc 1998;18:900-7.
Civitareale D, Lonigro R, Sinclair AJ, Di Lauro R. A thyroid- specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. EMBO J 1989;8:2537-42.
Moldvay J, Jackel M, Bogos K, Soltész I, Agócs L, Kovács G, et al. The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas. Pathol Oncol Res 2004;10:85-8.
Roh MS, Hong SH. Utility of thyroid transcription factor- 1 and cytokeratin 20 in identifying the origin of metastatic carcinomas of cervical lymph nodes. J Korean Med Sci 2002;17:512-7.
Su YC, Hsu YC, Chai CY. Role of TTF-1, CK20, and CK7 immunohistochemistry for diagnosis of primary and secondary lung adenocarcinoma. Kaohsiung J Med Sci 2006;22:14-9.
Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 2003;27:303-10.
Park SY, Kim BH, Kim JH, Lee S, Kang GH. Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma. Arch Pathol Lab Med 2007;131:1561-7.