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A Case of Hypersensitivity Pneumonitis Following Placenta Extract Injection

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2009, v.66 no.6, pp.471-476








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Abstract

Human placenta contains various kinds of nutritional elements essential for embryonic development. Currently, human placenta extracts are widely overused in Korea to improve certain health conditions (postmenopausal syndrome, liver function, and cosmetic purposes) without scientific evidence that they actually work. The use of placenta extracts should be restricted, due to a lack of systematic research on the therapeutic effectiveness and adverse results from these treatments. While the common adverse effects that have been reported are fever, rash, itching, nausea, vomiting, breast pain, and rare cases of anaphylactic shock, there have been no reports of pulmonary complications such as hypersensitivity pneumonitis. Recently, we experienced a patient with hypersensitivity pneumonitis following a placenta extract injection. To our knowledge, this is the first case of hypersensitivity pneumonitis associated with placenta extract use.

keywords
Placenta, Placenta extract, Hypersensitivity pneumonitis

Reference

1.

Park NJ. Safety, efficacy and limitations of medical use of placental extract. J Korean Med Assoc 2005;48:1013-21.

2.

Shinde V, Dhalwal K, Paradkar AR, Mahadik KR, Kadam SS. Evaluation of in-vitro antioxidant activity of human placental extract. Pharmacologyonline 2006;3:172-9.

3.

Sur TK, Biswas TK, Ali L, Mukherjee B. Anti-inflammatory and anti-platelet aggregation activity of human placental extract. Acta Pharmacol Sin 2003;24:187-92.

4.

Liu KX, Kato Y, Kaku T, Sugiyama Y. Human placental extract stimulates liver regeneration in rats. Biol Pharm Bull 1998;21:44-9.

5.

Kong MH, Lee EJ, Lee SY, Cho SJ, Hong YS, Park SB. Effect of human placental extract on menopausal symptoms, fatigue, and risk factors for cardiovascular disease in middle-aged Korean women. Menopause 2008;15:296-303.

6.

Pal P, Mallick S, Mandal SK, Das M, Dutta AK, Datta PK, et al. A human placental extract: in vivo and in vitro assessments of its melanocyte growth and pigment- inducing activities. Int J Dermatol 2002;41:760-7.

7.

Woda BA. Hypersensitivity pneumonitis: an immunopathology review. Arch Pathol Lab Med 2008;132:204-5.

8.

Glazer CS, Rose CS, Lynch DA. Clinical and radiologic manifestations of hypersensitivity pneumonitis. J Thorac Imaging 2002;17:261-72.

9.

Baur X. Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. J Allergy Clin Immunol 1995;95:1004-10.

10.

Timmer SJ, Amundson DE, Malone JD. Hypersensitivity pneumonitis following anthrax vaccination. Chest 2002;122:741-5.

11.

Son CH, Kim HI, Kim KN, Lee KN, Lee CU, Roh MS, et al. Moxifloxacin-associated drug hypersensitivity syndrome with drug-induced hypersensitivity pneumonitis. J Investig Allergol Clin Immunol 2008;18:72-3.

12.

Silva CI, Churg A, Müller NL. Hypersensitivity pneumonitis: spectrum of high-resolution CT and pathologic findings. AJR Am J Roentgenol 2007;188:334-44.

13.

Kwon KY, Choi WI, Ko SM. Small airway diseases: clinical characteristics and pathological interpretation. Korean J Pathol 2006;40:389-98.

14.

Schuyler M, Cormier Y. The diagnosis of hypersensitivity pneumonitis. Chest 1997;111:534-6.

15.

Allen MB, Cockwell P, Page RL. Pulmonary and cutaneous vasculitis following hepatitis B vaccination. Thorax 1993;48:580-1.

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