바로가기메뉴

본문 바로가기 주메뉴 바로가기

A Case of Disseminated Mycobacterium intracellulare Infection in an Immunocompromised Host

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2009, v.67 no.1, pp.32-36









  • Downloaded
  • Viewed

Abstract

We report a case of disseminated Mycobacterium intracellulare infection in a 31-year-old man who had been diagnosed as having dermatomyositis and systemic lupus erythematosus 3-years prior. The patient developed a left pleural effusion M. intracellulare was repeatedly isolated from the pleural fluid. After antimycobacterial treatment, the patient’s pleural effusion resolved, but a left knee joint effusion developed newly and M. intracellulare was cultured from the joint fluid. At present, the patient has been taking antimycobacterial medication for 15 months but his left knee joint fluid remains positive for M. intracellulare. To our knowledge, this is the second reported case of disseminated NTM infection in a non-HIV infected patient in Korea.

keywords
Mycobacterium avium complex, Disseminated infection, Immunocompromised host, Pleural effusion, Arthritis

Reference

1.

Park SU, Koh WJ, Kwon OJ, Park HY, Jun HJ, Joo EJ, et al. Acute pneumonia and empyema caused by Mycobacterium intracellulare. Intern Med 2006;45:1007-10.

2.

Koh WJ, Kwon OJ. Diagnosis and treatment of nontuberculous mycobacterial lung disease. Korean J Med 2008;74:120-31.

3.

Kim SS, Rhie EJ, Ko GJ, Choi HS, Oh HE, Kim JM, et al. A Case of Mycobacterium avium pulmonary disease with massive pleural effusion in an HIV-negative, nonimmunosuppressed patient: using PCR-restriction fragment length polymorphism assay. Infect Chemother 2004;36:381-5.

4.

Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007;175:367-416.

5.

Lee CW, Sung HD, Choi BM, Kim CW, Jun SJ, Min SJ. Mycobacterium Avium arthritis with extra-articular abscess in a patient with mixed connective tissue disease. Korean J Intern Med 2003;18:119-21.

6.

Jang EY, Kim MY, Kim JW, Song EH, Pack KM, Chung YP, et al. A case of vertebral osteomyelitis due to Mycobacterium intracellulare. Infect Chemother 2007;39:172-5.

7.

Kwak SY, Bae SY, Yun WK, Kim MY, Kim YJ, Choi MK, et al. Mycobacterium intracellulare pulmonary infection accompanied with pleural effusion. Korean J Med 2008;75:475-8.

8.

Song JY, Park CW, Kee SY, Choi WS, Kang EY, Sohn JW, et al. Disseminated Mycobacterium avium complex infection in an immunocompetent pregnant woman. BMC Infect Dis 2006;6:154.

9.

Lee H, Park HJ, Cho SN, Bai GH, Kim SJ. Species identification of mycobacteria by PCR-restriction fragment length polymorphism of the rpoB gene. J Clin Microbiol 2000;38:2966-71.

10.

Inderlied CB, Kemper CA, Bermudez LE. The Mycobacterium avium complex. Clin Microbiol Rev 1993;6:266-310.

11.

Benson CA, Kaplan JE, Masur H, Pau A, Holmes KK. Treating opportunistic infections among HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America. MMWR Recomm Rep 2004;53:1-112.

12.

Chetchotisakd P, Kiertiburanakul S, Mootsikapun P, Assanasen S, Chaiwarith R, Anunnatsiri S. Disseminated nontuberculous mycobacterial infection in patients who are not infected with HIV in Thailand. Clin Infect Dis 2007;45:421-7.

13.

Yi SH, Choi JH, Choi MH, Shin DW, Choi JH, Kim TY, et al. Disseminated Mycobacterium avium complex infection in a patient with acquired immunodeficiency syndrome. Infect Chemother 2008;40:297-300.

14.

Park KW, Kwon HH, Chung SH, Kim KC, Choe JY, Lee YH. A case of tenosynovitis due to Mycobacterium intracellulare in a patient with rheumatoid arthritis. Infect Chemother 2007;39:59-62.

15.

Nightingale SD, Byrd LT, Southern PM, Jockusch JD, Cal SX, Wynne BA. Incidence of Mycobacterium avium- intracellulare complex bacteremia in human immunodeficiency virus-positive patients. J Infect Dis 1992;165:1082-5.

16.

Horsburgh CR Jr, Gettings J, Alexander LN, Lennox JL. Disseminated Mycobacterium avium complex disease among patients infected with human immunodeficiency virus, 1985-2000. Clin Infect Dis 2001;33:1938-43.

17.

Lai CC, Lee LN, Ding LW, Yu CJ, Hsueh PR, Yang PC. Emergence of disseminated infections due to nontuberculous mycobacteria in non-HIV-infected patients, including immunocompetent and immunocompromised patients in a university hospital in Taiwan. J Infect 2006;53:77-84.

Tuberculosis & Respiratory Diseases