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Tuberculosis & Respiratory Diseases

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Vol.67 No.2
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A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2009, v.67 no.2, pp.145-147







& (2009). A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer. Tuberculosis & Respiratory Diseases, 67(2), 145-147.
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Abstract

Etoposide is a semi-synthetic derivative of podophyllotoxin that is effective against many cancers including small cell lung cancer. We report a case of etoposide-induced anaphylaxis in a 51-year-old woman who tolerated etoposide during her first cycle chemotherapy regimen. During the second cycle, she complained of generalized urticaria and dyspnea 5 minutes after being infused with etoposide. She recovered completely with antihistamine, corticosteroid and fluid replacement. The intradermal skin test with etoposide showed a clear positive immediate reaction. This case suggests that etoposide can induce IgE-mediated anaphylaxis.

keywords
Etoposide, Anaphylaxis, Small cell lung carcinoma, Skin tests

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