Intrathoracic Desmoid Tumor Mimicking Pleural Mass: A Case Report

Desmoid tumor (fibromatosis) is a histologically benign fibrous neoplasm showing locally infiltrating growth. This type of tumor commonly occurs in the abdomen, but intrathoracic desmoid tumor is uncommon. To date, 12 casesof intrathoracic desmoid tumor protruding into the pleural cavity, radiologically mimicking pleural masses, have been reported. Here, we report on a case of intrathoracic desmoid tumor protruding into the pleural cavity, andpartially covered by parietal pleura. The main preoperative differential diagnoses included pleural solitary fibrous tumor, inflammatory pseudotumor or malignant mesothelioma. A near-total mass excision was performed. Pathologically, the tumor was composed of a paucicellular arrangement of spindle-shaped cells with fibromyxoid stroma. The resection margin was partially involved with spindle cells present. On histochemical staining, the spindle cells were strongly positive for vimentin and negative for CD34, consistent with a desmoid tumor. The patient wasstable without further adjuvant treatment during 6-years of follow-up.

keywords: Fibromatosis, Abdominal, Pleura

Reference

Weiss SW, Glodblum JR. Chapter 9. Fibromatoses. In: Weiss SW, Glodblum JR, editors. Enzinger and Weiss’s soft tissue tumors. 5th ed. St. Louis: Mosby; 2008. p.227-56.

Kim KH, Seo YH, Kuh JH, Kim MH. Huge intraabdominal and thoracic desmoid tumor: surgical experience in one case. Korean J Thorac Cardiovasc Surg 2003;36:623-6.

Winer-Muram HT, Bowman LC, Parham D. Intrathoracic desmoid tumor: CT and MRI appearance. South Med J 1994;87:1007-9.

Okamura H, Murayama S, Murakami J, Kawanami T, Zaizen Y, Ohgami H, et al. CT manifestations of pediatric intrathoracic desmoid tumors. Pediatr Radiol 1995;25 Suppl 1:S202-4.

Wilson RW, Gallateau-Salle F, Moran CA. Desmoid tumors of the pleura: a clinicopathologic mimic of localized fibrous tumor. Mod Pathol 1999;12:9-14.

Takeshima Y, Nakayori F, Nakano T, Shimizu K, Yamashita Y, Toge T, et al. Extra-abdominal desmoid tumor presenting as an intrathoracic tumor: case report and literature review. Pathol Int 2001;51:824-8.

Dosios TJ, Angouras DC, Floros DG. Primary desmoid tumor of the posterior mediastinum. Ann Thorac Surg 1998;66:2098-9.

Iqbal M, Rossoff LJ, Kahn L, Lackner RP. Intrathoracic desmoid tumor mimicking primary lung neoplasm. Ann Thorac Surg 2001;71:1698-700.

Meyerson SL, D'Amico TA. Intrathoracic desmoid tumor: brief report and review of literature. J Thorac Oncol 2008;3:656-9.

10.

Kim MJ, Park KJ, Sun JS, Kim JH, Choi H. Intrathoracic desmoid tumor: a case report and radiological evaluation. J Korean Radiol Soc 2007;57:31-5.

11.

Andino L, Cagle PT, Murer B, Lu L, Popper HH, Galateau-Salle F, et al. Pleuropulmonary desmoid tumors: immunohistochemical comparison with solitary fibrous tumors and assessment of beta-catenin and cyclin D1 expression. Arch Pathol Lab Med 2006;130:1503-9.

12.

Skene AI, Barr L, A'Hern RP, Fisher C, Meirion Thomas J. Multimodality treatment in the control of deep musculoaponeurotic fibromatosis. Br J Surg 1998;85:655-8.

13.

Tajima S, Hironaka M, Oshikawa K, Bando M, Ohno S, Saito K, et al. Intrathoracic sporadic desmoid tumor with the beta-catenin gene mutation in exon 3 and activated cyclin D1. Respiration 2006;73:558-61.

14.

Lee JC, Thomas JM, Phillips S, Fisher C, Moskovic E. Aggressive fibromatosis: MRI features with pathologic correlation. AJR Am J Roentgenol 2006;186:247-54.

15.

Schwickerath J, Kunzig HJ. Spontaneous malignant transformation of extra-abdominal fibromatosis to fibrosarcoma. Geburtshilfe Frauenheilkd 1995;55:173-5.

바로가기메뉴

Article Contents

Vol.67 No.5

Intrathoracic Desmoid Tumor Mimicking Pleural Mass: A Case Report

Abstract

Reference

Tuberculosis & Respiratory Diseases